Expression of ICMT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Isoprenylcysteine carboxyl methyltransferase

Protein class

Enzymes, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA032024	HPA032025

GENE INFORMATION
Gene name	ICMT (HGNC Symbol)
Synonyms	HSTE14, PCCMT, PPMT
Description	Isoprenylcysteine carboxyl methyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.31
Chromosome location (bp)	6221193 - 6235972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116237 (version 83.38)
Entrez gene	23463
UniProt	O60725 (UniProt - Evidence at protein level)
neXtProt	NX_O60725
Antibodypedia	ICMT antibodies

PROTEIN BROWSER

ICMT-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ICMT-001 ENSP00000343552 ENST00000343813	O60725 [Direct mapping] Protein-S-isoprenylcysteine O-methyltransferase A0A024R4F6 [Target identity:100%; Query identity:100%] Protein-S-isoprenylcysteine O-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0001889 [liver development] GO:0003880 [protein C-terminal carboxyl O-methyltransferase activity] GO:0004671 [protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] GO:0006481 [C-terminal protein methylation] GO:0006612 [protein targeting to membrane] GO:0008104 [protein localization] GO:0008140 [cAMP response element binding protein binding] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035264 [multicellular organism growth] GO:0046498 [S-adenosylhomocysteine metabolic process] GO:0046499 [S-adenosylmethioninamine metabolic process] GO:0046578 [regulation of Ras protein signal transduction] Show all	284 aa 31.9 kDa	No	6