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ICMT

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GENERAL INFORMATION

Gene name

 ICMT

Gene description

 Isoprenylcysteine carboxyl methyltransferase

Protein class

 Enzymes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ICMT (HGNC Symbol)

Synonyms

 HSTE14, PCCMT, PPMT

Description

 Isoprenylcysteine carboxyl methyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.31

Chromosome location (bp)

 6221193 - 6235972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116237 (version 83.38)

Entrez gene

 23463

UniProt

 O60725 (UniProt - Evidence at protein level)

neXtProt

 NX_O60725

Antibodypedia

 ICMT antibodies

PROTEIN BROWSER
ICMT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ICMT-001
ENSP00000343552
ENST00000343813
O60725 [Direct mapping]
Protein-S-isoprenylcysteine O-methyltransferase
A0A024R4F6 [Target identity:100%; Query identity:100%]
Protein-S-isoprenylcysteine O-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0001889 [liver development]
GO:0003880 [protein C-terminal carboxyl O-methyltransferase activity]
GO:0004671 [protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006464 [cellular protein modification process]
GO:0006479 [protein methylation]
GO:0006481 [C-terminal protein methylation]
GO:0006612 [protein targeting to membrane]
GO:0008104 [protein localization]
GO:0008140 [cAMP response element binding protein binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035264 [multicellular organism growth]
GO:0046498 [S-adenosylhomocysteine metabolic process]
GO:0046499 [S-adenosylmethioninamine metabolic process]
GO:0046578 [regulation of Ras protein signal transduction]
Show all
 284 aa
31.9 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.