Tissue expression of SLC35D1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC35D1
Gene description	Solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC35D1 (HGNC Symbol)
Synonyms	KIAA0260, UGTREL7
Description	Solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 (HGNC Symbol)
Entrez gene summary	Glycosylation of cellular glycoconjugates occurs in the endoplasmic reticulum (ER) and Golgi compartment, and requires transport of nucleotide sugars from the cytosol into the lumen of the ER and Golgi by specific transporters. The protein encoded by this gene resides in the ER, and transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to the ER lumen. It may participate in glucuronidation and/or chondroitin sulfate biosynthesis. Mutations in this gene are associated with Schneckenbecken dysplasia.[provided by RefSeq, Sep 2009]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	66999332 - 67054099
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116704 (version 83.38)
Entrez gene	23169
UniProt	Q9NTN3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NTN3
Antibodypedia	SLC35D1 antibodies

PROTEIN BROWSER

SLC35D1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35D1-001 ENSP00000235345 ENST00000235345	Q9NTN3 [Direct mapping] UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005461 [UDP-glucuronic acid transmembrane transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006065 [UDP-glucuronate biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008643 [carbohydrate transport] GO:0015165 [pyrimidine nucleotide-sugar transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015781 [pyrimidine nucleotide-sugar transport] GO:0015787 [UDP-glucuronic acid transport] GO:0016021 [integral component of membrane] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0048706 [embryonic skeletal system development] GO:0052695 [cellular glucuronidation] GO:0055085 [transmembrane transport] GO:0090481 [pyrimidine nucleotide-sugar transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	355 aa 39.2 kDa	No	>9