Tissue expression of WLS - Summary - The Human Protein Atlas

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WLS

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	WLS
Gene description	Wntless Wnt ligand secretion mediator
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA069520
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	WLS (HGNC Symbol)
Synonyms	C1orf139, EVI, FLJ23091, GPR177, mig-14, MRP, wls
Description	Wntless Wnt ligand secretion mediator (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	68098473 - 68233120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116729 (version 83.38)
Entrez gene	79971
UniProt	Q5T9L3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T9L3
Antibodypedia	WLS antibodies

PROTEIN BROWSER

WLS-001	WLS-002	WLS-003	WLS-004	WLS-009	WLS-012	WLS-013	WLS-014	WLS-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WLS-001 ENSP00000262348 ENST00000262348	Q5T9L3 [Direct mapping] Protein wntless homolog Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0017147 [Wnt-protein binding] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030666 [endocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0061357 [positive regulation of Wnt protein secretion] GO:0070062 [extracellular exosome] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	541 aa 62.3 kDa	No	8
WLS-002 ENSP00000360015 ENST00000370976	Q5T9L3 [Direct mapping] Protein wntless homolog Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0017147 [Wnt-protein binding] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030666 [endocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0061357 [positive regulation of Wnt protein secretion] GO:0070062 [extracellular exosome] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	450 aa 51.6 kDa	No	7
WLS-003 ENSP00000346829 ENST00000354777	Q5T9L3 [Direct mapping] Protein wntless homolog Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001707 [mesoderm formation] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0009948 [anterior/posterior axis specification] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0030666 [endocytic vesicle membrane] GO:0030901 [midbrain development] GO:0030902 [hindbrain development] GO:0031017 [exocrine pancreas development] GO:0031410 [cytoplasmic vesicle] GO:0031852 [mu-type opioid receptor binding] GO:0031901 [early endosome membrane] GO:0032590 [dendrite membrane] GO:0032839 [dendrite cytoplasm] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0061357 [positive regulation of Wnt protein secretion] GO:0070062 [extracellular exosome] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	543 aa 62.6 kDa	No	8
WLS-004 ENSP00000360010 ENST00000370971	Q7Z430 [Direct mapping] Protein wntless homolog; Putative NFkB activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] Show all	127 aa 14.3 kDa	No	2
WLS-009 ENSP00000433111 ENST00000530486	E9PM62 [Direct mapping] Protein wntless homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] Show all	222 aa 26.2 kDa	No	1
WLS-012 ENSP00000436196 ENST00000471243	E9PQK1 [Direct mapping] Protein wntless homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] Show all	152 aa 18 kDa	No	0
WLS-013 ENSP00000433690 ENST00000533537	E9PJW4 [Direct mapping] Protein wntless homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] Show all	134 aa 15.8 kDa	No	1
WLS-014 ENSP00000431552 ENST00000534713	H0YCG9 [Direct mapping] Protein wntless homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] Show all	200 aa 23 kDa	No	3
WLS-015 ENSP00000360012 ENST00000370973	E9PKJ0 [Direct mapping] Protein wntless homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] Show all	122 aa 14.4 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.