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Most cancers showed weak to moderate cytoplasmic immunoreactivity with additional nuclear positivity in several cases. Gliomas and lymphomas as well as lung and stomach cancers were mainly negative.
GENE INFORMATION
Gene name
PRDM2 (HGNC Symbol)
Synonyms
HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2
Description
PR domain containing 2, with ZNF domain (HGNC Symbol)
Entrez gene summary
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Q13029 [Direct mapping] PR domain zinc finger protein 2
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q13029 [Direct mapping] PR domain zinc finger protein 2
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0046872 [metal ion binding]
Q13029 [Direct mapping] PR domain zinc finger protein 2
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
