Cell atlas - PRDM2 - The Human Protein Atlas

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PRDM2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleus

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PRDM2
Gene description	PR domain containing 2, with ZNF domain
Protein class	Enzymes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA005809
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & the Golgi apparatus.

Main location

Nucleus (supported), Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005809	A-431	Nucleus
	HPA005809	A-431	Golgi apparatus
	HPA005809	U-2 OS	Golgi apparatus
	HPA005809	U-251 MG	Nucleus
	HPA005809	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	PRDM2 (HGNC Symbol)
Synonyms	HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2
Description	PR domain containing 2, with ZNF domain (HGNC Symbol)
Entrez gene summary	This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Chromosome	1
Cytoband	p36.21
Chromosome location (bp)	13700198 - 13825079
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116731 (version 83.38)
Entrez gene	7799
UniProt	Q13029 (UniProt - Evidence at protein level)
neXtProt	NX_Q13029
Antibodypedia	PRDM2 antibodies

PROTEIN BROWSER

PRDM2-001	PRDM2-002	PRDM2-003	PRDM2-004	PRDM2-009	PRDM2-010	PRDM2-011	PRDM2-014	PRDM2-015	PRDM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRDM2-001 ENSP00000235372 ENST00000235372	Q13029 [Direct mapping] PR domain zinc finger protein 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0008340 [determination of adult lifespan] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0032355 [response to estradiol] GO:0034968 [histone lysine methylation] GO:0046872 [metal ion binding] Show all	1718 aa 188.9 kDa	No	0
PRDM2-002 ENSP00000365216 ENST00000376048	Q13029 [Direct mapping] PR domain zinc finger protein 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] Show all	226 aa 25.5 kDa	No	0
PRDM2-003 ENSP00000411103 ENST00000413440	Q13029 [Direct mapping] PR domain zinc finger protein 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0046872 [metal ion binding] Show all	1481 aa 162.1 kDa	No	0
PRDM2-004 ENSP00000341621 ENST00000343137	Q13029 [Direct mapping] PR domain zinc finger protein 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0046872 [metal ion binding] Show all	1481 aa 162.1 kDa	No	0
PRDM2-009 ENSP00000474273 ENST00000487453	S4R3F7 [Direct mapping] PR domain zinc finger protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		21 aa 2.3 kDa	No	0
PRDM2-010 ENSP00000423010 ENST00000484063	D6RAA0 [Direct mapping] PR domain zinc finger protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	153 aa 17.3 kDa	No	0
PRDM2-011 ENSP00000425028 ENST00000503842	D6RED5 [Direct mapping] PR domain zinc finger protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.8 kDa	No	0
PRDM2-014 ENSP00000384430 ENST00000407521	D6RJM6 [Direct mapping] PR domain zinc finger protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.6 kDa	No	0
PRDM2-015 ENSP00000426737 ENST00000505823	D6RED5 [Direct mapping] PR domain zinc finger protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.8 kDa	No	0
PRDM2-201 ENSP00000312352 ENST00000311066	Q13029 [Direct mapping] PR domain zinc finger protein 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0046872 [metal ion binding] Show all	1682 aa 185 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.