Expression of WARS2 in cancer - Summary

CANCER ATLAS

Gene description

Tryptophanyl tRNA synthetase 2, mitochondrial

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA069692

GENE INFORMATION
Gene name	WARS2 (HGNC Symbol)
Synonyms	TrpRS
Description	Tryptophanyl tRNA synthetase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p12
Chromosome location (bp)	119031216 - 119140671
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116874 (version 83.38)
Entrez gene	10352
UniProt	Q9UGM6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGM6
Antibodypedia	WARS2 antibodies

PROTEIN BROWSER

WARS2-001	WARS2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WARS2-001 ENSP00000235521 ENST00000235521	Q9UGM6 [Direct mapping] Tryptophan--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001570 [vasculogenesis] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004830 [tryptophan-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006436 [tryptophanyl-tRNA aminoacylation] GO:0010467 [gene expression] Show all	360 aa 40.1 kDa	No	0
WARS2-002 ENSP00000358434 ENST00000369426	Q9UGM6 [Direct mapping] Tryptophan--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004830 [tryptophan-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006436 [tryptophanyl-tRNA aminoacylation] GO:0010467 [gene expression] Show all	220 aa 24.8 kDa	No	0