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WARS2

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GENERAL INFORMATION

Gene name

 WARS2

Gene description

 Tryptophanyl tRNA synthetase 2, mitochondrial

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria. In addition localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

Additional location

 In addition localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA069692
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria. In addition localized to the plasma membrane.

Main location

 Mitochondria (supported)

Additional location

 Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA069692 MCF7 Mitochondria
HPA069692 RT4 Plasma membrane
Mitochondria
HPA069692 U-2 OS Mitochondria

GENE INFORMATION

Gene name

 WARS2 (HGNC Symbol)

Synonyms

 TrpRS

Description

 Tryptophanyl tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p12

Chromosome location (bp)

 119031216 - 119140671

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116874 (version 83.38)

Entrez gene

 10352

UniProt

 Q9UGM6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UGM6

Antibodypedia

 WARS2 antibodies

PROTEIN BROWSER
WARS2-001
WARS2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WARS2-001
ENSP00000235521
ENST00000235521
Q9UGM6 [Direct mapping]
Tryptophan--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001570 [vasculogenesis]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004830 [tryptophan-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006436 [tryptophanyl-tRNA aminoacylation]
GO:0010467 [gene expression]
Show all
 360 aa
40.1 kDa 		No 0
WARS2-002
ENSP00000358434
ENST00000369426
Q9UGM6 [Direct mapping]
Tryptophan--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004830 [tryptophan-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006436 [tryptophanyl-tRNA aminoacylation]
GO:0010467 [gene expression]
Show all
 220 aa
24.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.