Tissue expression of HAO2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HAO2
Gene description	Hydroxyacid oxidase 2 (long chain)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (kidney, liver)
GTEx:	Group enriched (liver, kidney)
FANTOM5:	Group enriched (liver, kidney)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, kidney)

GENE INFORMATION
Gene name	HAO2 (HGNC Symbol)
Synonyms	GIG16, HAOX2
Description	Hydroxyacid oxidase 2 (long chain) (HGNC Symbol)
Entrez gene summary	This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	p12
Chromosome location (bp)	119368779 - 119394130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116882 (version 83.38)
Entrez gene	51179
UniProt	Q9NYQ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYQ3
Antibodypedia	HAO2 antibodies

PROTEIN BROWSER

HAO2-001	HAO2-002	HAO2-003	HAO2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAO2-001 ENSP00000354314 ENST00000361035	Q9NYQ3 [Direct mapping] Hydroxyacid oxidase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003973 [(S)-2-hydroxy-acid oxidase activity] GO:0005102 [receptor binding] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0019395 [fatty acid oxidation] GO:0052852 [very-long-chain-(S)-2-hydroxy-acid oxidase activity] GO:0052853 [long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity] GO:0052854 [medium-chain-(S)-2-hydroxy-acid oxidase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	364 aa 40.4 kDa	No	0
HAO2-002 ENSP00000316339 ENST00000325945	Q9NYQ3 [Direct mapping] Hydroxyacid oxidase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003973 [(S)-2-hydroxy-acid oxidase activity] GO:0005102 [receptor binding] GO:0005777 [peroxisome] GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0019395 [fatty acid oxidation] GO:0052852 [very-long-chain-(S)-2-hydroxy-acid oxidase activity] GO:0052853 [long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity] GO:0052854 [medium-chain-(S)-2-hydroxy-acid oxidase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	351 aa 38.8 kDa	No	0
HAO2-003 ENSP00000393955 ENST00000457318	Q5QP02 [Direct mapping] Hydroxyacid oxidase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	186 aa 21.3 kDa	No	0
HAO2-201 ENSP00000483507 ENST00000622548	Q9NYQ3 [Direct mapping] Hydroxyacid oxidase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003973 [(S)-2-hydroxy-acid oxidase activity] GO:0005102 [receptor binding] GO:0005777 [peroxisome] GO:0010181 [FMN binding] GO:0016491 [oxidoreductase activity] GO:0019395 [fatty acid oxidation] GO:0052852 [very-long-chain-(S)-2-hydroxy-acid oxidase activity] GO:0052853 [long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity] GO:0052854 [medium-chain-(S)-2-hydroxy-acid oxidase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	351 aa 38.8 kDa	No	0