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NT5C1A

GENERAL INFORMATION

Gene name

 NT5C1A

Gene description

 5'-nucleotidase, cytosolic IA

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle, heart muscle)
GTEx:Tissue enhanced (skeletal muscle, cerebellum)
FANTOM5:Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in a subset of renal tubules and striated muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA050283 , HPA054158
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION

Gene name

 NT5C1A (HGNC Symbol)

Synonyms

 CN-I, CN-IA, CN1, CN1A, MGC119199, MGC119201

Description

 5'-nucleotidase, cytosolic IA (HGNC Symbol)

Entrez gene summary

 Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 39659121 - 39672038

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116981 (version 83.38)

Entrez gene

 84618

UniProt

 Q9BXI3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BXI3

Antibodypedia

 NT5C1A antibodies

PROTEIN BROWSER
NT5C1A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NT5C1A-001
ENSP00000235628
ENST00000235628
Q9BXI3 [Direct mapping]
Cytosolic 5'-nucleotidase 1A
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006195 [purine nucleotide catabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0008253 [5'-nucleotidase activity]
GO:0009116 [nucleoside metabolic process]
GO:0009117 [nucleotide metabolic process]
GO:0009128 [purine nucleoside monophosphate catabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046085 [adenosine metabolic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
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 368 aa
41 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.