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Weak to moderate nuclear positivity was observed in most cancer tissues. Fraction of cells in few gliomas showed strong cytoplasmic staining. Lymphomas, renal, liver and endometrial cancers were mostly negative.
GENE INFORMATION
Gene name
KDM5B (HGNC Symbol)
Synonyms
CT31, JARID1B, PLU-1, PPP1R98, RBBP2H1A
Description
Lysine (K)-specific demethylase 5B (HGNC Symbol)
Entrez gene summary
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing resultsi n multiple transcript variants. [provided by RefSeq, Sep 2015]
THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0007338 [single fertilization] GO:0008270 [zinc ion binding] GO:0009791 [post-embryonic development] GO:0010628 [positive regulation of gene expression] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0033601 [positive regulation of mammary gland epithelial cell proliferation] GO:0034647 [histone demethylase activity (H3-trimethyl-K4 specific)] GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0034721 [histone H3-K4 demethylation, trimethyl-H3-K4-specific] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048511 [rhythmic process] GO:0055114 [oxidation-reduction process] GO:0060444 [branching involved in mammary gland duct morphogenesis] GO:0060763 [mammary duct terminal end bud growth] GO:0060992 [response to fungicide] GO:0061038 [uterus morphogenesis] GO:0070306 [lens fiber cell differentiation] GO:2000864 [regulation of estradiol secretion]
B3KV94 [Direct mapping] Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_a; Lysine-specific demethylase 5B; cDNA FLJ16281 fis, clone NT2RI3003104, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA
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THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0055114 [oxidation-reduction process]
