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KDM5B

GENERAL INFORMATION

Gene name

 KDM5B

Gene description

 Lysine (K)-specific demethylase 5B

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression, most abundant in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA027179 , CAB068193
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 KDM5B (HGNC Symbol)

Synonyms

 CT31, JARID1B, PLU-1, PPP1R98, RBBP2H1A

Description

 Lysine (K)-specific demethylase 5B (HGNC Symbol)

Entrez gene summary

 This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing resultsi n multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 202724491 - 202809470

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117139 (version 83.38)

Entrez gene

 10765

UniProt

 Q9UGL1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UGL1

Antibodypedia

 KDM5B antibodies

PROTEIN BROWSER
KDM5B-001
KDM5B-002
KDM5B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KDM5B-001
ENSP00000356234
ENST00000367265
Q9UGL1 [Direct mapping]
Lysine-specific demethylase 5B
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007338 [single fertilization]
GO:0008270 [zinc ion binding]
GO:0009791 [post-embryonic development]
GO:0010628 [positive regulation of gene expression]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0032453 [histone demethylase activity (H3-K4 specific)]
GO:0033601 [positive regulation of mammary gland epithelial cell proliferation]
GO:0034647 [histone demethylase activity (H3-trimethyl-K4 specific)]
GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)]
GO:0034720 [histone H3-K4 demethylation]
GO:0034721 [histone H3-K4 demethylation, trimethyl-H3-K4-specific]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:0055114 [oxidation-reduction process]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0060763 [mammary duct terminal end bud growth]
GO:0060992 [response to fungicide]
GO:0061038 [uterus morphogenesis]
GO:0070306 [lens fiber cell differentiation]
GO:2000864 [regulation of estradiol secretion]
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 1544 aa
175.7 kDa 		No 0
KDM5B-002
ENSP00000235790
ENST00000235790
B3KV94 [Direct mapping]
Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_a; Lysine-specific demethylase 5B; cDNA FLJ16281 fis, clone NT2RI3003104, highly similar to Homo sapiens Jumonji, AT rich interactive domain 1B (RBP2-like) (JARID1B), mRNA
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0055114 [oxidation-reduction process]
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 1275 aa
145.1 kDa 		No 0
KDM5B-003
ENSP00000356233
ENST00000367264
Q9UGL1 [Direct mapping]
Lysine-specific demethylase 5B
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0032453 [histone demethylase activity (H3-K4 specific)]
GO:0034647 [histone demethylase activity (H3-trimethyl-K4 specific)]
GO:0034648 [histone demethylase activity (H3-dimethyl-K4 specific)]
GO:0034720 [histone H3-K4 demethylation]
GO:0034721 [histone H3-K4 demethylation, trimethyl-H3-K4-specific]
GO:0048511 [rhythmic process]
GO:0055114 [oxidation-reduction process]
Show all
 1580 aa
179.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.