Tissue expression of CDK18 - Summary - The Human Protein Atlas

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CDK18

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CDK18
Gene description	Cyclin-dependent kinase 18
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (heart muscle)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in all tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 1 antibody. HPA045429
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CDK18 (HGNC Symbol)
Synonyms	PCTAIRE3, PCTK3
Description	Cyclin-dependent kinase 18 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	205504595 - 205532793
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117266 (version 83.38)
Entrez gene	5129
UniProt	Q07002 (UniProt - Evidence at protein level)
neXtProt	NX_Q07002
Antibodypedia	CDK18 antibodies

PROTEIN BROWSER

CDK18-001	CDK18-003	CDK18-005	CDK18-006	CDK18-007	CDK18-015	CDK18-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK18-001 ENSP00000353176 ENST00000360066	Q07002 [Direct mapping] Cyclin-dependent kinase 18 A0A024R996 [Target identity:100%; Query identity:100%] PCTAIRE protein kinase 3, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0006468 [protein phosphorylation] GO:0051726 [regulation of cell cycle] Show all	474 aa 54.4 kDa	No	0
CDK18-003 ENSP00000399082 ENST00000429964	Q07002 [Direct mapping] Cyclin-dependent kinase 18 A0A024R996 [Target identity:100%; Query identity:100%] PCTAIRE protein kinase 3, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0006468 [protein phosphorylation] GO:0051726 [regulation of cell cycle] Show all	474 aa 54.4 kDa	No	0
CDK18-005 ENSP00000423408 ENST00000478560	D6RA44 [Direct mapping] Cyclin-dependent kinase 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	180 aa 20.8 kDa	No	0
CDK18-006 ENSP00000423665 ENST00000506784	Q07002 [Direct mapping] Cyclin-dependent kinase 18 A0A024R980 [Target identity:100%; Query identity:100%] PCTAIRE protein kinase 3, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0006468 [protein phosphorylation] GO:0051726 [regulation of cell cycle] Show all	504 aa 57.6 kDa	No	0
CDK18-007 ENSP00000391324 ENST00000419301	A0A0A0MSJ6 [Direct mapping] Cyclin-dependent kinase 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	284 aa 32.5 kDa	No	0
CDK18-015 ENSP00000426368 ENST00000506215	D6RGH0 [Direct mapping] Cyclin-dependent kinase 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7.3 kDa	No	0
CDK18-019 ENSP00000397831 ENST00000443813	D6R9B0 [Direct mapping] Cyclin-dependent kinase 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		159 aa 18.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.