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ECE1

CANCER ATLAS

Gene description

 Endothelin converting enzyme 1

Protein class

 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001490
HPA013616

GENE INFORMATION

Gene name

 ECE1 (HGNC Symbol)

Synonyms

 ECE

Description

 Endothelin converting enzyme 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 21217247 - 21345504

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117298 (version 83.38)

Entrez gene

 1889

UniProt

 P42892 (UniProt - Evidence at protein level)

neXtProt

 NX_P42892

Antibodypedia

 ECE1 antibodies

PROTEIN BROWSER
ECE1-001
ECE1-002
ECE1-005
ECE1-006
ECE1-007
ECE1-008
ECE1-010
ECE1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ECE1-001
ENSP00000405088
ENST00000415912
P42892 [Direct mapping]
Endothelin-converting enzyme 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001921 [positive regulation of receptor recycling]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007507 [heart development]
GO:0009897 [external side of plasma membrane]
GO:0010814 [substance P catabolic process]
GO:0010815 [bradykinin catabolic process]
GO:0010816 [calcitonin catabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0017046 [peptide hormone binding]
GO:0019229 [regulation of vasoconstriction]
GO:0031302 [intrinsic component of endosome membrane]
GO:0031982 [vesicle]
GO:0033093 [Weibel-Palade body]
GO:0034959 [endothelin maturation]
GO:0042447 [hormone catabolic process]
GO:0042733 [embryonic digit morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043583 [ear development]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
Show all
 754 aa
85.6 kDa 		No 1
ECE1-002
ENSP00000364028
ENST00000374893
P42892 [Direct mapping]
Endothelin-converting enzyme 1
A0A024RAF7 [Target identity:100%; Query identity:100%]
Endothelin converting enzyme 1, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001921 [positive regulation of receptor recycling]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0007507 [heart development]
GO:0008217 [regulation of blood pressure]
GO:0009897 [external side of plasma membrane]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010814 [substance P catabolic process]
GO:0010815 [bradykinin catabolic process]
GO:0010816 [calcitonin catabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0017046 [peptide hormone binding]
GO:0019229 [regulation of vasoconstriction]
GO:0030141 [secretory granule]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031302 [intrinsic component of endosome membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031982 [vesicle]
GO:0033093 [Weibel-Palade body]
GO:0034959 [endothelin maturation]
GO:0035994 [response to muscle stretch]
GO:0042312 [regulation of vasodilation]
GO:0042447 [hormone catabolic process]
GO:0042493 [response to drug]
GO:0042733 [embryonic digit morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043583 [ear development]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:0046686 [response to cadmium ion]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060037 [pharyngeal system development]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
Show all
 770 aa
87.2 kDa 		No 1
ECE1-005
ENSP00000349581
ENST00000357071
P42892 [Direct mapping]
Endothelin-converting enzyme 1
A0A024RAB0 [Target identity:100%; Query identity:100%]
Endothelin converting enzyme 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001921 [positive regulation of receptor recycling]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007507 [heart development]
GO:0009897 [external side of plasma membrane]
GO:0010814 [substance P catabolic process]
GO:0010815 [bradykinin catabolic process]
GO:0010816 [calcitonin catabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0017046 [peptide hormone binding]
GO:0019229 [regulation of vasoconstriction]
GO:0031302 [intrinsic component of endosome membrane]
GO:0031982 [vesicle]
GO:0033093 [Weibel-Palade body]
GO:0034959 [endothelin maturation]
GO:0042447 [hormone catabolic process]
GO:0042733 [embryonic digit morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043583 [ear development]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
Show all
 758 aa
85.8 kDa 		No 1
ECE1-006
ENSP00000264205
ENST00000264205
P42892 [Direct mapping]
Endothelin-converting enzyme 1
A0A024RAB2 [Target identity:100%; Query identity:100%]
Endothelin converting enzyme 1, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001921 [positive regulation of receptor recycling]
GO:0003100 [regulation of systemic arterial blood pressure by endothelin]
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007507 [heart development]
GO:0009897 [external side of plasma membrane]
GO:0010814 [substance P catabolic process]
GO:0010815 [bradykinin catabolic process]
GO:0010816 [calcitonin catabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0017046 [peptide hormone binding]
GO:0019229 [regulation of vasoconstriction]
GO:0031302 [intrinsic component of endosome membrane]
GO:0031982 [vesicle]
GO:0033093 [Weibel-Palade body]
GO:0034959 [endothelin maturation]
GO:0042447 [hormone catabolic process]
GO:0042733 [embryonic digit morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043583 [ear development]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
Show all
 767 aa
87 kDa 		No 1
ECE1-007
ENSP00000431856
ENST00000473505
E9PJG1 [Direct mapping]
Endothelin-converting enzyme 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
Show all
 77 aa
8.8 kDa 		No 0
ECE1-008
ENSP00000388439
ENST00000436918
B4DKB2 [Direct mapping]
Endothelin-converting enzyme 1; cDNA FLJ59212, highly similar to Endothelin-converting enzyme 1 (EC 3.4.24.71)
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
 738 aa
83.6 kDa 		No 1
ECE1-010
ENSP00000436633
ENST00000481130
E9PHZ1 [Direct mapping]
Endothelin-converting enzyme 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
 134 aa
14.5 kDa 		No 1
ECE1-011
ENSP00000432860
ENST00000527991
E9PN99 [Direct mapping]
Endothelin-converting enzyme 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
 103 aa
11.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.