Cell atlas - ECE1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ECE1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ECE1
Gene description	Endothelin converting enzyme 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ECE1 (HGNC Symbol)
Synonyms	ECE
Description	Endothelin converting enzyme 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	21217247 - 21345504
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117298 (version 83.38)
Entrez gene	1889
UniProt	P42892 (UniProt - Evidence at protein level)
neXtProt	NX_P42892
Antibodypedia	ECE1 antibodies

PROTEIN BROWSER

ECE1-001	ECE1-002	ECE1-005	ECE1-006	ECE1-007	ECE1-008	ECE1-010	ECE1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECE1-001 ENSP00000405088 ENST00000415912	P42892 [Direct mapping] Endothelin-converting enzyme 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001921 [positive regulation of receptor recycling] GO:0003100 [regulation of systemic arterial blood pressure by endothelin] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007507 [heart development] GO:0009897 [external side of plasma membrane] GO:0010814 [substance P catabolic process] GO:0010815 [bradykinin catabolic process] GO:0010816 [calcitonin catabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0017046 [peptide hormone binding] GO:0019229 [regulation of vasoconstriction] GO:0031302 [intrinsic component of endosome membrane] GO:0031982 [vesicle] GO:0033093 [Weibel-Palade body] GO:0034959 [endothelin maturation] GO:0042447 [hormone catabolic process] GO:0042733 [embryonic digit morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043583 [ear development] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] Show all	754 aa 85.6 kDa	No	1
ECE1-002 ENSP00000364028 ENST00000374893	P42892 [Direct mapping] Endothelin-converting enzyme 1 A0A024RAF7 [Target identity:100%; Query identity:100%] Endothelin converting enzyme 1, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0001921 [positive regulation of receptor recycling] GO:0003100 [regulation of systemic arterial blood pressure by endothelin] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007507 [heart development] GO:0008217 [regulation of blood pressure] GO:0009897 [external side of plasma membrane] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010814 [substance P catabolic process] GO:0010815 [bradykinin catabolic process] GO:0010816 [calcitonin catabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0017046 [peptide hormone binding] GO:0019229 [regulation of vasoconstriction] GO:0030141 [secretory granule] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031302 [intrinsic component of endosome membrane] GO:0031410 [cytoplasmic vesicle] GO:0031982 [vesicle] GO:0033093 [Weibel-Palade body] GO:0034959 [endothelin maturation] GO:0035994 [response to muscle stretch] GO:0042312 [regulation of vasodilation] GO:0042447 [hormone catabolic process] GO:0042493 [response to drug] GO:0042733 [embryonic digit morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043583 [ear development] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0046686 [response to cadmium ion] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0070062 [extracellular exosome] GO:0070372 [regulation of ERK1 and ERK2 cascade] Show all	770 aa 87.2 kDa	No	1
ECE1-005 ENSP00000349581 ENST00000357071	P42892 [Direct mapping] Endothelin-converting enzyme 1 A0A024RAB0 [Target identity:100%; Query identity:100%] Endothelin converting enzyme 1, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001921 [positive regulation of receptor recycling] GO:0003100 [regulation of systemic arterial blood pressure by endothelin] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007507 [heart development] GO:0009897 [external side of plasma membrane] GO:0010814 [substance P catabolic process] GO:0010815 [bradykinin catabolic process] GO:0010816 [calcitonin catabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0017046 [peptide hormone binding] GO:0019229 [regulation of vasoconstriction] GO:0031302 [intrinsic component of endosome membrane] GO:0031982 [vesicle] GO:0033093 [Weibel-Palade body] GO:0034959 [endothelin maturation] GO:0042447 [hormone catabolic process] GO:0042733 [embryonic digit morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043583 [ear development] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] Show all	758 aa 85.8 kDa	No	1
ECE1-006 ENSP00000264205 ENST00000264205	P42892 [Direct mapping] Endothelin-converting enzyme 1 A0A024RAB2 [Target identity:100%; Query identity:100%] Endothelin converting enzyme 1, isoform CRA_c Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001921 [positive regulation of receptor recycling] GO:0003100 [regulation of systemic arterial blood pressure by endothelin] GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007507 [heart development] GO:0009897 [external side of plasma membrane] GO:0010814 [substance P catabolic process] GO:0010815 [bradykinin catabolic process] GO:0010816 [calcitonin catabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0017046 [peptide hormone binding] GO:0019229 [regulation of vasoconstriction] GO:0031302 [intrinsic component of endosome membrane] GO:0031982 [vesicle] GO:0033093 [Weibel-Palade body] GO:0034959 [endothelin maturation] GO:0042447 [hormone catabolic process] GO:0042733 [embryonic digit morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043583 [ear development] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] Show all	767 aa 87 kDa	No	1
ECE1-007 ENSP00000431856 ENST00000473505	E9PJG1 [Direct mapping] Endothelin-converting enzyme 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] Show all	77 aa 8.8 kDa	No	0
ECE1-008 ENSP00000388439 ENST00000436918	B4DKB2 [Direct mapping] Endothelin-converting enzyme 1; cDNA FLJ59212, highly similar to Endothelin-converting enzyme 1 (EC 3.4.24.71) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	738 aa 83.6 kDa	No	1
ECE1-010 ENSP00000436633 ENST00000481130	E9PHZ1 [Direct mapping] Endothelin-converting enzyme 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	134 aa 14.5 kDa	No	1
ECE1-011 ENSP00000432860 ENST00000527991	E9PN99 [Direct mapping] Endothelin-converting enzyme 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	103 aa 11.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.