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P3H1

CANCER ATLAS

Gene description

 Prolyl 3-hydroxylase 1

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012113
HPA016980

GENE INFORMATION

Gene name

 P3H1 (HGNC Symbol)

Synonyms

 GROS1, LEPRE1, LEPRECAN, MGC117314

Description

 Prolyl 3-hydroxylase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 42746335 - 42767084

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117385 (version 83.38)

Entrez gene

 64175

UniProt

 Q32P28 (UniProt - Evidence at protein level)

neXtProt

 NX_Q32P28

Antibodypedia

 P3H1 antibodies

PROTEIN BROWSER
P3H1-001
P3H1-002
P3H1-012
P3H1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P3H1-001
ENSP00000296388
ENST00000296388
Q32P28 [Direct mapping]
Prolyl 3-hydroxylase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005506 [iron ion binding]
GO:0005518 [collagen binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0018126 [protein hydroxylation]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0019797 [procollagen-proline 3-dioxygenase activity]
GO:0030198 [extracellular matrix organization]
GO:0031418 [L-ascorbic acid binding]
GO:0032403 [protein complex binding]
GO:0032963 [collagen metabolic process]
GO:0032991 [macromolecular complex]
GO:0050708 [regulation of protein secretion]
GO:0050821 [protein stabilization]
GO:0055114 [oxidation-reduction process]
GO:0060348 [bone development]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:1901874 [negative regulation of post-translational protein modification]
Show all
 736 aa
83.4 kDa 		Yes 0
P3H1-002
ENSP00000236040
ENST00000236040
Q32P28 [Direct mapping]
Prolyl 3-hydroxylase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005506 [iron ion binding]
GO:0005518 [collagen binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0018126 [protein hydroxylation]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0019797 [procollagen-proline 3-dioxygenase activity]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030278 [regulation of ossification]
GO:0031418 [L-ascorbic acid binding]
GO:0032403 [protein complex binding]
GO:0032963 [collagen metabolic process]
GO:0032991 [macromolecular complex]
GO:0050708 [regulation of protein secretion]
GO:0050821 [protein stabilization]
GO:0055114 [oxidation-reduction process]
GO:0060348 [bone development]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:1901874 [negative regulation of post-translational protein modification]
Show all
 804 aa
90.6 kDa 		Yes 0
P3H1-012
ENSP00000361604
ENST00000372526
E2QRI1 [Direct mapping]
Prolyl 3-hydroxylase 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 207 aa
23.1 kDa 		Yes 0
P3H1-201
ENSP00000380245
ENST00000397054
Q32P28 [Direct mapping]
Prolyl 3-hydroxylase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005506 [iron ion binding]
GO:0005518 [collagen binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0018126 [protein hydroxylation]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0019797 [procollagen-proline 3-dioxygenase activity]
GO:0030198 [extracellular matrix organization]
GO:0031418 [L-ascorbic acid binding]
GO:0032403 [protein complex binding]
GO:0032963 [collagen metabolic process]
GO:0032991 [macromolecular complex]
GO:0050708 [regulation of protein secretion]
GO:0050821 [protein stabilization]
GO:0055114 [oxidation-reduction process]
GO:0060348 [bone development]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:1901874 [negative regulation of post-translational protein modification]
Show all
 697 aa
78.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.