Expression of SLC19A2 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 19 (thiamine transporter), member 2

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006119	HPA016599

GENE INFORMATION
Gene name	SLC19A2 (HGNC Symbol)
Synonyms	THTR1, TRMA
Description	Solute carrier family 19 (thiamine transporter), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	169463909 - 169486003
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117479 (version 83.38)
Entrez gene	10560
UniProt	O60779 (UniProt - Evidence at protein level)
neXtProt	NX_O60779
Antibodypedia	SLC19A2 antibodies

PROTEIN BROWSER

SLC19A2-001	SLC19A2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC19A2-001 ENSP00000236137 ENST00000236137	O60779 [Direct mapping] Thiamine transporter 1 A0A024R928 [Target identity:100%; Query identity:100%] Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0008517 [folic acid transporter activity] GO:0015234 [thiamine transmembrane transporter activity] GO:0015403 [thiamine uptake transmembrane transporter activity] GO:0015884 [folic acid transport] GO:0015888 [thiamine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042723 [thiamine-containing compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0071934 [thiamine transmembrane transport] Show all	497 aa 55.4 kDa	No	>9
SLC19A2-002 ENSP00000356778 ENST00000367804	O60779 [Direct mapping] Thiamine transporter 1 A0A024R8Y5 [Target identity:100%; Query identity:100%] Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0008517 [folic acid transporter activity] GO:0015234 [thiamine transmembrane transporter activity] GO:0015403 [thiamine uptake transmembrane transporter activity] GO:0015884 [folic acid transport] GO:0015888 [thiamine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042723 [thiamine-containing compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0071934 [thiamine transmembrane transport] Show all	296 aa 32.9 kDa	No	6