Cell atlas - SLC19A2 - The Human Protein Atlas

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SLC19A2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	SLC19A2
Gene description	Solute carrier family 19 (thiamine transporter), member 2
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006119
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006119	A-431	Cytosol
	HPA006119	U-2 OS	Cytosol
	HPA006119	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SLC19A2 (HGNC Symbol)
Synonyms	THTR1, TRMA
Description	Solute carrier family 19 (thiamine transporter), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	169463909 - 169486003
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117479 (version 83.38)
Entrez gene	10560
UniProt	O60779 (UniProt - Evidence at protein level)
neXtProt	NX_O60779
Antibodypedia	SLC19A2 antibodies

PROTEIN BROWSER

SLC19A2-001	SLC19A2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC19A2-001 ENSP00000236137 ENST00000236137	O60779 [Direct mapping] Thiamine transporter 1 A0A024R928 [Target identity:100%; Query identity:100%] Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0008517 [folic acid transporter activity] GO:0015234 [thiamine transmembrane transporter activity] GO:0015403 [thiamine uptake transmembrane transporter activity] GO:0015884 [folic acid transport] GO:0015888 [thiamine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042723 [thiamine-containing compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0071934 [thiamine transmembrane transport] Show all	497 aa 55.4 kDa	No	>9
SLC19A2-002 ENSP00000356778 ENST00000367804	O60779 [Direct mapping] Thiamine transporter 1 A0A024R8Y5 [Target identity:100%; Query identity:100%] Solute carrier family 19 (Thiamine transporter), member 2, isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0006855 [drug transmembrane transport] GO:0008517 [folic acid transporter activity] GO:0015234 [thiamine transmembrane transporter activity] GO:0015403 [thiamine uptake transmembrane transporter activity] GO:0015884 [folic acid transport] GO:0015888 [thiamine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042723 [thiamine-containing compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0071934 [thiamine transmembrane transport] Show all	296 aa 32.9 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.