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DR1

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GENERAL INFORMATION

Gene name

 DR1

Gene description

 Down-regulator of transcription 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Mouse

 Localized to the Nucleoli in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA055308
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA055308 HEK 293 Nucleus
HPA055308 PC-3 Nucleus
HPA055308 U-2 OS Nucleus

MOUSE CELLS

Main location

 Nucleoli

Additional location

 Nucleus

Mouse gene

 ENSMUSG00000029265 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location
HPA055308 NIH 3T3 Nucleus
Nucleoli

GENE INFORMATION

Gene name

 DR1 (HGNC Symbol)

Synonyms

 NC2-BETA, NC2B

Description

 Down-regulator of transcription 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p22.1

Chromosome location (bp)

 93345888 - 93369498

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117505 (version 83.38)

Entrez gene

 1810

UniProt

 Q01658 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01658

Antibodypedia

 DR1 antibodies

PROTEIN BROWSER
DR1-001
DR1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DR1-001
ENSP00000359295
ENST00000370272
Q01658 [Direct mapping]
Protein Dr1
Q658N3 [Target identity:100%; Query identity:100%]
Down-regulator of transcription 1, TBP-binding (Negative cofactor 2), isoform CRA_a; Putative uncharacterized protein DKFZp666G145; cDNA FLJ32979 fis, clone TESTI2017775, highly similar to TATA-BINDING PROTEIN-ASSOCIATED PHOSPHOPROTEIN
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0017025 [TBP-class protein binding]
GO:0043966 [histone H3 acetylation]
GO:0046982 [protein heterodimerization activity]
Show all
 176 aa
19.4 kDa 		No 0
DR1-002
ENSP00000359290
ENST00000370267
Q01658 [Direct mapping]
Protein Dr1
Q658N3 [Target identity:100%; Query identity:100%]
Down-regulator of transcription 1, TBP-binding (Negative cofactor 2), isoform CRA_a; Putative uncharacterized protein DKFZp666G145; cDNA FLJ32979 fis, clone TESTI2017775, highly similar to TATA-BINDING PROTEIN-ASSOCIATED PHOSPHOPROTEIN
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0017025 [TBP-class protein binding]
GO:0043966 [histone H3 acetylation]
GO:0046982 [protein heterodimerization activity]
Show all
 176 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.