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CNN3

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GENERAL INFORMATION

Gene name

 CNN3

Gene description

 Calponin 3, acidic

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & actin filaments.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Actin filaments (validated), Cytosol (validated)

Mouse

 Localized to the Actin filaments, Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB009849 , HPA051237
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & actin filaments.

Main location

 Actin filaments (validated), Cytosol (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051237 CACO-2 Actin filaments
HPA051237 U-2 OS Actin filaments
Cytosol
HPA051237 U-251 MG Actin filaments
Cytosol
CAB009849 CACO-2 Actin filaments
CAB009849 U-2 OS Actin filaments
Cytosol
CAB009849 U-251 MG Actin filaments
Cytosol

MOUSE CELLS

Main location

 Actin filaments, Cytosol

Mouse gene

 ENSMUSG00000053931 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA051237 NIH 3T3 Actin filaments
Cytosol

GENE INFORMATION

Gene name

 CNN3

Synonyms

Description

 Calponin 3, acidic (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p21.3

Chromosome location (bp)

 94896949 - 94927278

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117519 (version 83.38)

Entrez gene

 1266

UniProt

 Q15417 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15417

Antibodypedia

 CNN3 antibodies

PROTEIN BROWSER
CNN3-001
CNN3-002
CNN3-201
CNN3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNN3-001
ENSP00000359225
ENST00000370206
Q15417 [Direct mapping]
Calponin-3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0030425 [dendrite]
GO:0030855 [epithelial cell differentiation]
GO:0031032 [actomyosin structure organization]
GO:0032780 [negative regulation of ATPase activity]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
Show all
 329 aa
36.4 kDa 		No 0
CNN3-002
ENSP00000401452
ENST00000415017
E9PDU6 [Direct mapping]
Calponin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0031032 [actomyosin structure organization]
Show all
 185 aa
20.2 kDa 		No 0
CNN3-201
ENSP00000377752
ENST00000394202
Q15417 [Direct mapping]
Calponin-3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0030855 [epithelial cell differentiation]
GO:0031032 [actomyosin structure organization]
Show all
 283 aa
31.4 kDa 		No 0
CNN3-202
ENSP00000440081
ENST00000545882
Q15417 [Direct mapping]
Calponin-3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0030855 [epithelial cell differentiation]
GO:0031032 [actomyosin structure organization]
Show all
 288 aa
31.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.