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Most malignancies were negative. Thyroid cancers and several ovarian cancers showed moderate cytoplasmic staining.
GENE INFORMATION
Gene name
PLPPR5 (HGNC Symbol)
Synonyms
LPPR5, PAP2, PAP2D, PRG5
Description
Phospholipid phosphatase related 5 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
