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PLPPR5

GENERAL INFORMATION

Gene name

 PLPPR5

Gene description

 Phospholipid phosphatase related 5

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, testis)
GTEx:Group enriched (cerebral cortex, hippocampus, hypothalamus, caudate, testis)
FANTOM5:Group enriched (caudate, hippocampus, brain, testis, retina, cerebellum)

Protein evidence

 Evidence at transcript level

Protein expression

 Expression in CNS and Leydig cells of testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA018072
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, hippocampus, hypothalamus, caudate, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, hippocampus, brain, testis, retina, cerebellum)

GENE INFORMATION

Gene name

 PLPPR5 (HGNC Symbol)

Synonyms

 LPPR5, PAP2, PAP2D, PRG5

Description

 Phospholipid phosphatase related 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p21.3

Chromosome location (bp)

 98890245 - 99005032

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000117598 (version 83.38)

Entrez gene

 163404

UniProt

 Q32ZL2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q32ZL2

Antibodypedia

 PLPPR5 antibodies

PROTEIN BROWSER
PLPPR5-001
PLPPR5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLPPR5-001
ENSP00000359207
ENST00000370188
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
 316 aa
34.9 kDa 		No 6
PLPPR5-002
ENSP00000263177
ENST00000263177
Q32ZL2 [Target identity:100%; Query identity:100%]
Lipid phosphate phosphatase-related protein type 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005887 [integral component of plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0007165 [signal transduction]
GO:0042577 [lipid phosphatase activity]
GO:0046839 [phospholipid dephosphorylation]
Show all
 321 aa
35.4 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.