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Cases of breast, endometrial, renal, liver cancers and malignant lymphomas and gliomas showed moderate cytoplasmic positivity. Remaining malignancies were weakly stained or negative.
A majority of malignant tissues displayed weak to moderate cytoplasmic and occasional membranous positivity. Malignant carcinoids, head & neck cancers, thyroid cancers and malignant gliomas were mainly negative.
GENE INFORMATION
Gene name
SERPINC1 (HGNC Symbol)
Synonyms
AT3, ATIII, MGC22579
Description
Serpin peptidase inhibitor, clade C (antithrombin), member 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
