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SERPINC1

GENERAL INFORMATION

Gene name

 SERPINC1

Gene description

 Serpin peptidase inhibitor, clade C (antithrombin), member 1

Protein class

 Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct positivity in plasma. Also expressed at lower levels in the cytoplasm of several cell types.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA001816 , HPA024007 , CAB016790
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Colon
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 SERPINC1 (HGNC Symbol)

Synonyms

 AT3, ATIII, MGC22579

Description

 Serpin peptidase inhibitor, clade C (antithrombin), member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

Chromosome

 1

Cytoband

 q25.1

Chromosome location (bp)

 173903804 - 173917378

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117601 (version 83.38)

Entrez gene

 462

UniProt

 P01008 (UniProt - Evidence at protein level)

neXtProt

 NX_P01008

Antibodypedia

 SERPINC1 antibodies

PROTEIN BROWSER
SERPINC1-001
SERPINC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERPINC1-001
ENSP00000356671
ENST00000367698
P01008 [Direct mapping]
Antithrombin-III
A0A024R944 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade C (Antithrombin), member 1, isoform CRA_a
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0050728 [negative regulation of inflammatory response]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:2000266 [regulation of blood coagulation, intrinsic pathway]
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 464 aa
52.6 kDa 		Yes 0
SERPINC1-201
ENSP00000478688
ENST00000617423
Q8TCE1 [Direct mapping]
Antithrombin-III; SERPINC1 protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005615 [extracellular space]
GO:0008201 [heparin binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:2000266 [regulation of blood coagulation, intrinsic pathway]
Show all
 259 aa
29.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.