Expression of NSL1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

NSL1, MIS12 kinetochore complex component

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045761

GENE INFORMATION
Gene name	NSL1 (HGNC Symbol)
Synonyms	C1orf48, DC8, DKFZP566O1646, MIS14
Description	NSL1, MIS12 kinetochore complex component (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	q32.3
Chromosome location (bp)	212726153 - 212791782
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117697 (version 83.38)
Entrez gene	25936
UniProt	Q96IY1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96IY1
Antibodypedia	NSL1 antibodies

PROTEIN BROWSER

NSL1-001	NSL1-002	NSL1-005	NSL1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NSL1-001 ENSP00000355944 ENST00000366977	Q96IY1 [Direct mapping] Kinetochore-associated protein NSL1 homolog Q53FM2 [Target identity:100%; Query identity:100%] Chromosome 1 open reading frame 48 variant; Chromosome 1 open reading frame 48, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000444 [MIS12/MIND type complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0051301 [cell division] Show all	281 aa 32.2 kDa	No	0
NSL1-002 ENSP00000355943 ENST00000366976	Q5SY74 [Direct mapping] Kinetochore-associated protein NSL1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 19.5 kDa	No	0
NSL1-005 ENSP00000355945 ENST00000366978	Q5SY76 [Direct mapping] Kinetochore-associated protein NSL1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		75 aa 8.5 kDa	No	0
NSL1-006 ENSP00000486783 ENST00000626725	Q96IY1 [Direct mapping] Kinetochore-associated protein NSL1 homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000444 [MIS12/MIND type complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0051301 [cell division] Show all	213 aa 24.1 kDa	No	0