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PROX1

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GENERAL INFORMATION

Gene name

 PROX1

Gene description

 Prospero homeobox 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (SH-SY5Y, Hep G2, RH-30)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA000842 , HPA001030
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, Hep G2, RH-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001030 Hep G2 Nucleoplasm
HPA001030 RH-30 Nucleoplasm
HPA000842 Hep G2 Nucleoplasm
HPA000842 RH-30 Nucleoplasm
Cytosol Intensity
HPA000842 U-2 OS Cytosol

GENE INFORMATION

Gene name

 PROX1

Synonyms

Description

 Prospero homeobox 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

 1

Cytoband

 q32.3

Chromosome location (bp)

 213983181 - 214041502

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117707 (version 83.38)

Entrez gene

 5629

UniProt

 Q92786 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92786

Antibodypedia

 PROX1 antibodies

PROTEIN BROWSER
PROX1-001
PROX1-002
PROX1-004
PROX1-006
PROX1-201
PROX1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PROX1-001
ENSP00000355925
ENST00000366958
Q92786 [Direct mapping]
Prospero homeobox protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001709 [cell fate determination]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001945 [lymph vessel development]
GO:0001946 [lymphangiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0002194 [hepatocyte cell migration]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0007623 [circadian rhythm]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0021516 [dorsal spinal cord development]
GO:0021542 [dentate gyrus development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0021915 [neural tube development]
GO:0030182 [neuron differentiation]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0030324 [lung development]
GO:0030910 [olfactory placode formation]
GO:0031016 [pancreas development]
GO:0031667 [response to nutrient levels]
GO:0042752 [regulation of circadian rhythm]
GO:0043049 [otic placode formation]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045446 [endothelial cell differentiation]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046619 [optic placode formation involved in camera-type eye formation]
GO:0048839 [inner ear development]
GO:0048845 [venous blood vessel morphogenesis]
GO:0050692 [DBD domain binding]
GO:0050693 [LBD domain binding]
GO:0055005 [ventricular cardiac myofibril assembly]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060214 [endocardium formation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060412 [ventricular septum morphogenesis]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0060421 [positive regulation of heart growth]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
GO:0061114 [branching involved in pancreas morphogenesis]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070365 [hepatocyte differentiation]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0072574 [hepatocyte proliferation]
GO:0090425 [acinar cell differentiation]
GO:0097150 [neuronal stem cell population maintenance]
GO:1901978 [positive regulation of cell cycle checkpoint]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000979 [positive regulation of forebrain neuron differentiation]
Show all
 737 aa
83.2 kDa 		No 0
PROX1-002
ENSP00000400694
ENST00000435016
Q92786 [Direct mapping]
Prospero homeobox protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001946 [lymphangiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0021516 [dorsal spinal cord development]
GO:0021542 [dentate gyrus development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0021915 [neural tube development]
GO:0030182 [neuron differentiation]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0030324 [lung development]
GO:0030910 [olfactory placode formation]
GO:0031016 [pancreas development]
GO:0042752 [regulation of circadian rhythm]
GO:0043049 [otic placode formation]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046619 [optic placode formation involved in camera-type eye formation]
GO:0048845 [venous blood vessel morphogenesis]
GO:0050692 [DBD domain binding]
GO:0050693 [LBD domain binding]
GO:0055005 [ventricular cardiac myofibril assembly]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060214 [endocardium formation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060412 [ventricular septum morphogenesis]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0060421 [positive regulation of heart growth]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070365 [hepatocyte differentiation]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0097150 [neuronal stem cell population maintenance]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000979 [positive regulation of forebrain neuron differentiation]
Show all
 737 aa
83.2 kDa 		No 0
PROX1-004
ENSP00000419517
ENST00000471129
C9JU29 [Direct mapping]
Prospero homeobox protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 230 aa
25.8 kDa 		No 0
PROX1-006
ENSP00000475357
ENST00000607425
U3KPY6 [Direct mapping]
Prospero homeobox protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 143 aa
15.6 kDa 		No 0
PROX1-201
ENSP00000261454
ENST00000261454
Q92786 [Direct mapping]
Prospero homeobox protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001946 [lymphangiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0021516 [dorsal spinal cord development]
GO:0021542 [dentate gyrus development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0021915 [neural tube development]
GO:0030182 [neuron differentiation]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0030324 [lung development]
GO:0030910 [olfactory placode formation]
GO:0031016 [pancreas development]
GO:0042752 [regulation of circadian rhythm]
GO:0043049 [otic placode formation]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046619 [optic placode formation involved in camera-type eye formation]
GO:0048845 [venous blood vessel morphogenesis]
GO:0050692 [DBD domain binding]
GO:0050693 [LBD domain binding]
GO:0055005 [ventricular cardiac myofibril assembly]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060214 [endocardium formation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060412 [ventricular septum morphogenesis]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0060421 [positive regulation of heart growth]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070365 [hepatocyte differentiation]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0097150 [neuronal stem cell population maintenance]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000979 [positive regulation of forebrain neuron differentiation]
Show all
 737 aa
83.2 kDa 		No 0
PROX1-202
ENSP00000420283
ENST00000498508
Q92786 [Direct mapping]
Prospero homeobox protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001946 [lymphangiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0021516 [dorsal spinal cord development]
GO:0021542 [dentate gyrus development]
GO:0021707 [cerebellar granule cell differentiation]
GO:0021915 [neural tube development]
GO:0030182 [neuron differentiation]
GO:0030240 [skeletal muscle thin filament assembly]
GO:0030324 [lung development]
GO:0030910 [olfactory placode formation]
GO:0031016 [pancreas development]
GO:0042752 [regulation of circadian rhythm]
GO:0043049 [otic placode formation]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046619 [optic placode formation involved in camera-type eye formation]
GO:0048845 [venous blood vessel morphogenesis]
GO:0050692 [DBD domain binding]
GO:0050693 [LBD domain binding]
GO:0055005 [ventricular cardiac myofibril assembly]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055009 [atrial cardiac muscle tissue morphogenesis]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060214 [endocardium formation]
GO:0060298 [positive regulation of sarcomere organization]
GO:0060412 [ventricular septum morphogenesis]
GO:0060414 [aorta smooth muscle tissue morphogenesis]
GO:0060421 [positive regulation of heart growth]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment]
GO:0070309 [lens fiber cell morphogenesis]
GO:0070365 [hepatocyte differentiation]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0097150 [neuronal stem cell population maintenance]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000979 [positive regulation of forebrain neuron differentiation]
Show all
 737 aa
83.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.