Fields »
ABOUT
HELP
BLOG
TNP1

GENERAL INFORMATION

Gene name

 TNP1

Gene description

 Transition protein 1 (during histone to protamine replacement)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in spermatids, testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044387
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 TNP1

Synonyms

Description

 Transition protein 1 (during histone to protamine replacement) (HGNC Symbol)

Entrez gene summary

 Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 216859458 - 216860064

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118245 (version 83.38)

Entrez gene

 7141

UniProt

 P09430 (UniProt - Evidence at protein level)

neXtProt

 NX_P09430

Antibodypedia

 TNP1 antibodies

PROTEIN BROWSER
TNP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNP1-001
ENSP00000236979
ENST00000236979
P09430 [Direct mapping]
Spermatid nuclear transition protein 1
Q4ZG82 [Target identity:100%; Query identity:100%]
Putative uncharacterized protein TNP1; Transition protein 1; Transition protein 1 (During histone to protamine replacement)
Show all
Predicted intracellular proteins
Show all
GO:0000012 [single strand break repair]
GO:0000786 [nucleosome]
GO:0001673 [male germ cell nucleus]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007286 [spermatid development]
GO:0007289 [spermatid nucleus differentiation]
GO:0007290 [spermatid nucleus elongation]
GO:0019953 [sexual reproduction]
GO:0030317 [sperm motility]
GO:0035042 [fertilization, exchange of chromosomal proteins]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 55 aa
6.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.