Cell atlas - CASP8AP2 - The Human Protein Atlas

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CASP8AP2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoli

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CASP8AP2
Gene description	Caspase 8 associated protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli & nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053573
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli & nuclear bodies.

Main location

Nucleoli (approved), Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053573	HEK 293	Nucleoli
			Nuclear bodies
			Cytosol
	HPA053573	RH-30	Nucleoli
			Nuclear bodies
			Cytosol
	HPA053573	U-2 OS	Nucleoli
	HPA053573	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	CASP8AP2 (HGNC Symbol)
Synonyms	CED-4, FLASH, FLJ11208, KIAA1315, RIP25
Description	Caspase 8 associated protein 2 (HGNC Symbol)
Entrez gene summary	This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
Chromosome	6
Cytoband	q15
Chromosome location (bp)	89829894 - 89874436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118412 (version 83.38)
Entrez gene	9994
UniProt
neXtProt
Antibodypedia	CASP8AP2 antibodies

PROTEIN BROWSER

CASP8AP2-001	CASP8AP2-004	CASP8AP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASP8AP2-001 ENSP00000485349 ENST00000419040	A0A096LP21 [Direct mapping] CASP8-associated protein 2 Show all	Predicted intracellular proteins Show all		361 aa 40.9 kDa	No	0
CASP8AP2-004 ENSP00000485346 ENST00000552401	A0A096LP21 [Direct mapping] CASP8-associated protein 2 Show all	Predicted intracellular proteins Show all		361 aa 40.9 kDa	No	0
CASP8AP2-201 ENSP00000478179 ENST00000551025	A0A087WTW5 [Direct mapping] CASP8-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0002020 [protease binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0042802 [identical protein binding] Show all	1972 aa 221.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.