Tissue expression of CASP8AP2 - Summary

GENERAL INFORMATION
Gene name	CASP8AP2
Gene description	Caspase 8 associated protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CASP8AP2 (HGNC Symbol)
Synonyms	CED-4, FLASH, FLJ11208, KIAA1315, RIP25
Description	Caspase 8 associated protein 2 (HGNC Symbol)
Entrez gene summary	This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
Chromosome	6
Cytoband	q15
Chromosome location (bp)	89829894 - 89874436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118412 (version 83.38)
Entrez gene	9994
UniProt
neXtProt
Antibodypedia	CASP8AP2 antibodies

PROTEIN BROWSER

CASP8AP2-001	CASP8AP2-004	CASP8AP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASP8AP2-001 ENSP00000485349 ENST00000419040	A0A096LP21 [Direct mapping] CASP8-associated protein 2 Show all	Predicted intracellular proteins Show all		361 aa 40.9 kDa	No	0
CASP8AP2-004 ENSP00000485346 ENST00000552401	A0A096LP21 [Direct mapping] CASP8-associated protein 2 Show all	Predicted intracellular proteins Show all		361 aa 40.9 kDa	No	0
CASP8AP2-201 ENSP00000478179 ENST00000551025	A0A087WTW5 [Direct mapping] CASP8-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0002020 [protease binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0042802 [identical protein binding] Show all	1972 aa 221.4 kDa	No	0