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Few cases of adenocarcinomas of cervix showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
SPACA1 (HGNC Symbol)
Synonyms
SAMP32
Description
Sperm acrosome associated 1 (HGNC Symbol)
Entrez gene summary
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]
