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Tumor necrosis factor, alpha-induced protein 3 (HGNC Symbol)
Entrez gene summary
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
Q5VXR0 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
Q5VXQ8 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
Q5VXQ9 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001922 [B-1 B cell homeostasis] GO:0002020 [protease binding] GO:0002237 [response to molecule of bacterial origin] GO:0002634 [regulation of germinal center formation] GO:0002677 [negative regulation of chronic inflammatory response] GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007166 [cell surface receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016579 [protein deubiquitination] GO:0016874 [ligase activity] GO:0019900 [kinase binding] GO:0031397 [negative regulation of protein ubiquitination] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032480 [negative regulation of type I interferon production] GO:0032495 [response to muramyl dipeptide] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032703 [negative regulation of interleukin-2 production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] GO:0034140 [negative regulation of toll-like receptor 3 signaling pathway] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034148 [negative regulation of toll-like receptor 5 signaling pathway] GO:0035871 [protein K11-linked deubiquitination] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043621 [protein self-association] GO:0045087 [innate immune response] GO:0045732 [positive regulation of protein catabolic process] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045779 [negative regulation of bone resorption] GO:0045824 [negative regulation of innate immune response] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050691 [regulation of defense response to virus by host] GO:0050727 [regulation of inflammatory response] GO:0050728 [negative regulation of inflammatory response] GO:0050869 [negative regulation of B cell activation] GO:0051259 [protein oligomerization] GO:0060548 [negative regulation of cell death] GO:0061043 [regulation of vascular wound healing] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0070429 [negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway] GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070530 [K63-linked polyubiquitin binding] GO:0070536 [protein K63-linked deubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0071108 [protein K48-linked deubiquitination] GO:0071222 [cellular response to lipopolysaccharide] GO:0071947 [protein deubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0072573 [tolerance induction to lipopolysaccharide] GO:0072666 [establishment of protein localization to vacuole] GO:0090291 [negative regulation of osteoclast proliferation] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903364 [positive regulation of cellular protein catabolic process] GO:2000347 [positive regulation of hepatocyte proliferation] GO:2000349 [negative regulation of CD40 signaling pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process]
A0A087WXL5 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
A0A087WVN3 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
A0A087WU80 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
D3TTY5 [Direct mapping] Truncated tumor necrosis factor alpha-induced protein 3; Tumor necrosis factor alpha-induced protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
A0A087X1N1 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
