Expression of AKAP7 in cancer - Summary

CANCER ATLAS

Gene description

A kinase (PRKA) anchor protein 7

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA027172	HPA028327

GENE INFORMATION
Gene name	AKAP7 (HGNC Symbol)
Synonyms	AKAP15, AKAP18
Description	A kinase (PRKA) anchor protein 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]
Chromosome	6
Cytoband	q23.2
Chromosome location (bp)	131135666 - 131283535
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000118507 (version 83.38)
Entrez gene	9465
UniProt	O43687 (UniProt - Evidence at protein level), Q9P0M2 (UniProt - Evidence at protein level)
neXtProt	NX_O43687, NX_Q9P0M2
Antibodypedia	AKAP7 antibodies

PROTEIN BROWSER

AKAP7-001	AKAP7-002	AKAP7-003	AKAP7-005	AKAP7-006	AKAP7-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKAP7-001 ENSP00000405252 ENST00000431975	Q9P0M2 [Direct mapping] A-kinase anchor protein 7 isoform gamma Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0019901 [protein kinase binding] GO:0034237 [protein kinase A regulatory subunit binding] GO:0051018 [protein kinase A binding] Show all	348 aa 39.5 kDa	No	0
AKAP7-002 ENSP00000418208 ENST00000474850	O43687 [Direct mapping] A-kinase anchor protein 7 isoforms alpha and beta Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001508 [action potential] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0008104 [protein localization] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0035556 [intracellular signal transduction] GO:0051018 [protein kinase A binding] GO:0060306 [regulation of membrane repolarization] GO:0071320 [cellular response to cAMP] GO:1901381 [positive regulation of potassium ion transmembrane transport] GO:1902261 [positive regulation of delayed rectifier potassium channel activity] Show all	104 aa 11.5 kDa	No	0
AKAP7-003 ENSP00000345149 ENST00000342266	O43687 [Direct mapping] A-kinase anchor protein 7 isoforms alpha and beta Q2TAJ5 [Target identity:100%; Query identity:100%] A kinase (PRKA) anchor protein 7; A kinase (PRKA) anchor protein 7, isoform CRA_c; A-kinase anchor protein 7 isoform alpha; cDNA, FLJ92081, Homo sapiens A kinase (PRKA) anchor protein 7 (AKAP7), transcriptvariant alpha, mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001508 [action potential] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0008104 [protein localization] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0035556 [intracellular signal transduction] GO:0051018 [protein kinase A binding] GO:0060306 [regulation of membrane repolarization] GO:0071320 [cellular response to cAMP] GO:1901381 [positive regulation of potassium ion transmembrane transport] GO:1902261 [positive regulation of delayed rectifier potassium channel activity] Show all	81 aa 9 kDa	No	0
AKAP7-005 ENSP00000441048 ENST00000541650	F5GXD1 [Direct mapping] A-kinase anchor protein 7 isoform gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		350 aa 40.1 kDa	No	0
AKAP7-006 ENSP00000263050 ENST00000263050	J3KN37 [Direct mapping] A-kinase anchor protein 7 isoform gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.3 kDa	No	0
AKAP7-010 ENSP00000446022 ENST00000537868	F5H4P9 [Direct mapping] A-kinase anchor protein 7 isoform gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 10 kDa	No	0