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AKAP7

GENERAL INFORMATION

Gene name

 AKAP7

Gene description

 A kinase (PRKA) anchor protein 7

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA027172 , HPA028327
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AKAP7 (HGNC Symbol)

Synonyms

 AKAP15, AKAP18

Description

 A kinase (PRKA) anchor protein 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]

Chromosome

 6

Cytoband

 q23.2

Chromosome location (bp)

 131135666 - 131283535

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000118507 (version 83.38)

Entrez gene

 9465

UniProt

 O43687 (UniProt - Evidence at protein level), Q9P0M2 (UniProt - Evidence at protein level)

neXtProt

 NX_O43687, NX_Q9P0M2

Antibodypedia

 AKAP7 antibodies

PROTEIN BROWSER
AKAP7-001
AKAP7-002
AKAP7-003
AKAP7-005
AKAP7-006
AKAP7-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP7-001
ENSP00000405252
ENST00000431975
Q9P0M2 [Direct mapping]
A-kinase anchor protein 7 isoform gamma
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008150 [biological_process]
GO:0019901 [protein kinase binding]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0051018 [protein kinase A binding]
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 348 aa
39.5 kDa 		No 0
AKAP7-002
ENSP00000418208
ENST00000474850
O43687 [Direct mapping]
A-kinase anchor protein 7 isoforms alpha and beta
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001508 [action potential]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0008104 [protein localization]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0051018 [protein kinase A binding]
GO:0060306 [regulation of membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]
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 104 aa
11.5 kDa 		No 0
AKAP7-003
ENSP00000345149
ENST00000342266
O43687 [Direct mapping]
A-kinase anchor protein 7 isoforms alpha and beta
Q2TAJ5 [Target identity:100%; Query identity:100%]
A kinase (PRKA) anchor protein 7; A kinase (PRKA) anchor protein 7, isoform CRA_c; A-kinase anchor protein 7 isoform alpha; cDNA, FLJ92081, Homo sapiens A kinase (PRKA) anchor protein 7 (AKAP7), transcriptvariant alpha, mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001508 [action potential]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0008104 [protein localization]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0051018 [protein kinase A binding]
GO:0060306 [regulation of membrane repolarization]
GO:0071320 [cellular response to cAMP]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]
Show all
 81 aa
9 kDa 		No 0
AKAP7-005
ENSP00000441048
ENST00000541650
F5GXD1 [Direct mapping]
A-kinase anchor protein 7 isoform gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 350 aa
40.1 kDa 		No 0
AKAP7-006
ENSP00000263050
ENST00000263050
J3KN37 [Direct mapping]
A-kinase anchor protein 7 isoform gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
9.3 kDa 		No 0
AKAP7-010
ENSP00000446022
ENST00000537868
F5H4P9 [Direct mapping]
A-kinase anchor protein 7 isoform gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 87 aa
10 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.