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Strong cytoplasmic and nuclear staining was observed in most endometrial cancers and some prostate, lung, ovarian and liver cancers. Tumor stroma was often distinctly stained. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
CTGF (HGNC Symbol)
Synonyms
CCN2, IGFBP8
Description
Connective tissue growth factor (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]