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Gene name

Class

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Chromosome

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In atlas

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Method

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SATB2
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SATB2

Gene description

SATB homeobox 2

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (rectum, colon, cerebral cortex)
GTEx:Tissue enhanced (colon)
FANTOM5:Tissue enhanced (appendix, brain)

Protein evidence

Evidence at protein level

Protein expression

Selective nuclear expression in large intestine and subsets of neuronal cells in brain.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 8 antibodies.
HPA001042 , HPA029543 , CAB023669 , CAB062562 , CAB067751 , CAB068229 , CAB068230 , CAB068231
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (rectum, colon, cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01020304050TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, brain)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina05101520253035Tags Per Million

GENE INFORMATION

Gene name

SATB2 (HGNC Symbol)

Synonyms

FLJ21474, KIAA1034

Description

SATB homeobox 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]

Chromosome

2

Cytoband

q33.1

Chromosome location (bp)

199269500 - 199471266

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119042 (version 83.38)

Entrez gene

23314

UniProt

Q9UPW6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UPW6

Antibodypedia

SATB2 antibodies

PROTEIN BROWSER

SATB2-001
SATB2-002
SATB2-003
SATB2-007
SATB2-010
SATB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SATB2-001
ENSP00000401112
ENST00000417098
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
A0A024R3U6 [Target identity:100%; Query identity:100%]
DNA-binding protein SATB
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001764 [neuron migration]
GO:0002076 [osteoblast development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009880 [embryonic pattern specification]
GO:0010468 [regulation of gene expression]
GO:0016363 [nuclear matrix]
GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0051216 [cartilage development]
GO:0060021 [palate development]
GO:0071310 [cellular response to organic substance]
Show all
733 aa
82.6 kDa
No 0
SATB2-002
ENSP00000405420
ENST00000457245
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
A0A024R3U6 [Target identity:100%; Query identity:100%]
DNA-binding protein SATB
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016363 [nuclear matrix]
GO:0043565 [sequence-specific DNA binding]
Show all
733 aa
82.6 kDa
No 0
SATB2-003
ENSP00000260926
ENST00000260926
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
A0A024R3U6 [Target identity:100%; Query identity:100%]
DNA-binding protein SATB
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016363 [nuclear matrix]
GO:0043565 [sequence-specific DNA binding]
Show all
733 aa
82.6 kDa
No 0
SATB2-007
ENSP00000388581
ENST00000428695
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016363 [nuclear matrix]
GO:0043565 [sequence-specific DNA binding]
Show all
615 aa
69.1 kDa
No 0
SATB2-010
ENSP00000388764
ENST00000443023
C9JR56 [Direct mapping]
DNA-binding protein SATB
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
674 aa
76 kDa
No 0
SATB2-201
ENSP00000483287
ENST00000614512
Q9UPW6 [Direct mapping]
DNA-binding protein SATB2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016363 [nuclear matrix]
GO:0043565 [sequence-specific DNA binding]
Show all
615 aa
69.1 kDa
No 0

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