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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ONECUT2
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ONECUT2

Gene description

One cut homeobox 2

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (gallbladder, duodenum)
GTEx:Tissue enhanced (liver, caudate)
FANTOM5:Tissue enhanced (gallbladder, caudate, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in gallbladder and small intestine.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA057058
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, caudate, small intestine)

GENE INFORMATION

Gene name

ONECUT2 (HGNC Symbol)

Synonyms

OC-2

Description

One cut homeobox 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

q21.31

Chromosome location (bp)

57435685 - 57491297

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119547 (version 83.38)

Entrez gene

9480

UniProt

O95948 (UniProt - Evidence at transcript level)

neXtProt

NX_O95948

Antibodypedia

ONECUT2 antibodies

PROTEIN BROWSER

ONECUT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ONECUT2-001
ENSP00000419185
ENST00000491143
O95948 [Direct mapping]
One cut domain family member 2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001889 [liver development]
GO:0001952 [regulation of cell-matrix adhesion]
GO:0002064 [epithelial cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [organ morphogenesis]
GO:0015629 [actin cytoskeleton]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031016 [pancreas development]
GO:0031018 [endocrine pancreas development]
GO:0042384 [cilium assembly]
GO:0045165 [cell fate commitment]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048935 [peripheral nervous system neuron development]
Show all
504 aa
54.3 kDa
No 0

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