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Few lymphomas, cervical cancers along with occasional colorectal, skin, head and neck cancers showed moderate nuclear positivity. Other cancer tissues were generally negative.
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007165 [signal transduction] GO:0010629 [negative regulation of gene expression] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0016925 [protein sumoylation] GO:0030183 [B cell differentiation] GO:0030217 [T cell differentiation] GO:0030517 [negative regulation of axon extension] GO:0032463 [negative regulation of protein homooligomerization] GO:0042803 [protein homodimerization activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0048671 [negative regulation of collateral sprouting] GO:0048672 [positive regulation of collateral sprouting] GO:0050773 [regulation of dendrite development] GO:2000171 [negative regulation of dendrite development]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0016925 [protein sumoylation] GO:0030517 [negative regulation of axon extension] GO:0032463 [negative regulation of protein homooligomerization] GO:0042803 [protein homodimerization activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0048671 [negative regulation of collateral sprouting] GO:0048672 [positive regulation of collateral sprouting] GO:0050773 [regulation of dendrite development] GO:2000171 [negative regulation of dendrite development]
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0016925 [protein sumoylation] GO:0030517 [negative regulation of axon extension] GO:0032463 [negative regulation of protein homooligomerization] GO:0042803 [protein homodimerization activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0048671 [negative regulation of collateral sprouting] GO:0048672 [positive regulation of collateral sprouting] GO:0050773 [regulation of dendrite development] GO:2000171 [negative regulation of dendrite development]
Q66LN6 [Target identity:100%; Query identity:100%] B-cell lymphoma/leukaemia 11A extra-short form
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0016925 [protein sumoylation] GO:0030517 [negative regulation of axon extension] GO:0032463 [negative regulation of protein homooligomerization] GO:0042803 [protein homodimerization activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0048671 [negative regulation of collateral sprouting] GO:0048672 [positive regulation of collateral sprouting] GO:0050773 [regulation of dendrite development] GO:2000171 [negative regulation of dendrite development]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)