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BCL11A

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GENERAL INFORMATION

Gene name

 BCL11A

Gene description

 B-cell CLL/lymphoma 11A (zinc finger protein)

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

RNA cell category

 Cell line enhanced (U-698, REH, MOLT-4, Daudi)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB014891 , HPA029003
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-698, REH, MOLT-4, Daudi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

 Nucleoplasm (validated)

Additional location

 Nuclear bodies (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB014891 A-431 Nucleoplasm
Nuclear bodies
CAB014891 U-2 OS Nucleoplasm
Nuclear bodies
CAB014891 U-251 MG Nucleoplasm
Nuclear bodies
HPA029003 A-431 Nucleoplasm
HPA029003 HEK 293 Nucleoplasm
HPA029003 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000000861 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA029003 NIH 3T3 No staining

GENE INFORMATION

Gene name

 BCL11A (HGNC Symbol)

Synonyms

 BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, ZNF856

Description

 B-cell CLL/lymphoma 11A (zinc finger protein) (HGNC Symbol)

Entrez gene summary

 This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p16.1

Chromosome location (bp)

 60451167 - 60553567

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119866 (version 83.38)

Entrez gene

 53335

UniProt

 Q9H165 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H165

Antibodypedia

 BCL11A antibodies

PROTEIN BROWSER
BCL11A-001
BCL11A-002
BCL11A-003
BCL11A-004
BCL11A-006
BCL11A-007
BCL11A-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCL11A-001
ENSP00000338774
ENST00000335712
Q9H165 [Direct mapping]
B-cell lymphoma/leukemia 11A
D6W5D9 [Target identity:100%; Query identity:100%]
B-cell CLL/lymphoma 11A (Zinc finger protein), isoform CRA_b; BCL11A B-cell CLL/lymphoma 11A (Zinc finger protein) isoform 1
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0010629 [negative regulation of gene expression]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0016925 [protein sumoylation]
GO:0030183 [B cell differentiation]
GO:0030217 [T cell differentiation]
GO:0030517 [negative regulation of axon extension]
GO:0032463 [negative regulation of protein homooligomerization]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048671 [negative regulation of collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0050773 [regulation of dendrite development]
GO:2000171 [negative regulation of dendrite development]
Show all
 835 aa
91.2 kDa 		No 0
BCL11A-002
ENSP00000349300
ENST00000356842
Q9H165 [Direct mapping]
B-cell lymphoma/leukemia 11A
D9YZV9 [Target identity:100%; Query identity:100%]
B-cell CLL/lymphoma 11A (Zinc finger protein) isoform 2; B-cell CLL/lymphoma 11A (Zinc finger protein), isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0016925 [protein sumoylation]
GO:0030517 [negative regulation of axon extension]
GO:0032463 [negative regulation of protein homooligomerization]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048671 [negative regulation of collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0050773 [regulation of dendrite development]
GO:2000171 [negative regulation of dendrite development]
Show all
 773 aa
83.9 kDa 		No 0
BCL11A-003
ENSP00000352648
ENST00000359629
Q9H165 [Direct mapping]
B-cell lymphoma/leukemia 11A
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0016925 [protein sumoylation]
GO:0030517 [negative regulation of axon extension]
GO:0032463 [negative regulation of protein homooligomerization]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048671 [negative regulation of collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0050773 [regulation of dendrite development]
GO:2000171 [negative regulation of dendrite development]
Show all
 243 aa
26.9 kDa 		No 0
BCL11A-004
ENSP00000487844
ENST00000409351
Q66LN6 [Target identity:100%; Query identity:100%]
B-cell lymphoma/leukaemia 11A extra-short form
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
15.7 kDa 		No 0
BCL11A-006
ENSP00000351307
ENST00000358510
Q9H165 [Direct mapping]
B-cell lymphoma/leukemia 11A
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0016925 [protein sumoylation]
GO:0030517 [negative regulation of axon extension]
GO:0032463 [negative regulation of protein homooligomerization]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048671 [negative regulation of collateral sprouting]
GO:0048672 [positive regulation of collateral sprouting]
GO:0050773 [regulation of dendrite development]
GO:2000171 [negative regulation of dendrite development]
Show all
 801 aa
87.6 kDa 		No 0
BCL11A-007
ENSP00000488390
ENST00000489516
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 191 aa
21.1 kDa 		No 0
BCL11A-013
ENSP00000488636
ENST00000479026
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 17 aa
2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.