Expression of IFIT3 in cancer - Summary

CANCER ATLAS

Gene description

Interferon-induced protein with tetratricopeptide repeats 3

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA059914

GENE INFORMATION
Gene name	IFIT3 (HGNC Symbol)
Synonyms	CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, RIG-G
Description	Interferon-induced protein with tetratricopeptide repeats 3 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q23.31
Chromosome location (bp)	89327894 - 89340971
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119917 (version 83.38)
Entrez gene	3437
UniProt	O14879 (UniProt - Evidence at protein level)
neXtProt	NX_O14879
Antibodypedia	IFIT3 antibodies

PROTEIN BROWSER

IFIT3-001	IFIT3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFIT3-001 ENSP00000360883 ENST00000371818	O14879 [Direct mapping] Interferon-induced protein with tetratricopeptide repeats 3 Q5T765 [Target identity:100%; Query identity:100%] Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_a; Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_b; cDNA FLJ75638, highly similar to Homo sapiens interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0008285 [negative regulation of cell proliferation] GO:0009615 [response to virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0035457 [cellular response to interferon-alpha] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0051607 [defense response to virus] GO:0060337 [type I interferon signaling pathway] Show all	490 aa 56 kDa	No	0
IFIT3-002 ENSP00000360876 ENST00000371811	O14879 [Direct mapping] Interferon-induced protein with tetratricopeptide repeats 3 Q5T765 [Target identity:100%; Query identity:100%] Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_a; Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_b; cDNA FLJ75638, highly similar to Homo sapiens interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0008285 [negative regulation of cell proliferation] GO:0009615 [response to virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0035457 [cellular response to interferon-alpha] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0051607 [defense response to virus] GO:0060337 [type I interferon signaling pathway] Show all	490 aa 56 kDa	No	0