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IFIT3

GENERAL INFORMATION

Gene name

 IFIT3

Gene description

 Interferon-induced protein with tetratricopeptide repeats 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA059914
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IFIT3 (HGNC Symbol)

Synonyms

 CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, RIG-G

Description

 Interferon-induced protein with tetratricopeptide repeats 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q23.31

Chromosome location (bp)

 89327894 - 89340971

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000119917 (version 83.38)

Entrez gene

 3437

UniProt

 O14879 (UniProt - Evidence at protein level)

neXtProt

 NX_O14879

Antibodypedia

 IFIT3 antibodies

PROTEIN BROWSER
IFIT3-001
IFIT3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFIT3-001
ENSP00000360883
ENST00000371818
O14879 [Direct mapping]
Interferon-induced protein with tetratricopeptide repeats 3
Q5T765 [Target identity:100%; Query identity:100%]
Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_a; Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_b; cDNA FLJ75638, highly similar to Homo sapiens interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035457 [cellular response to interferon-alpha]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 490 aa
56 kDa 		No 0
IFIT3-002
ENSP00000360876
ENST00000371811
O14879 [Direct mapping]
Interferon-induced protein with tetratricopeptide repeats 3
Q5T765 [Target identity:100%; Query identity:100%]
Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_a; Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_b; cDNA FLJ75638, highly similar to Homo sapiens interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035457 [cellular response to interferon-alpha]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 490 aa
56 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.