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HOXB3

CANCER ATLAS

Gene description

 Homeobox B3

Protein class

 Plasma proteins, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009860

GENE INFORMATION

Gene name

 HOXB3 (HGNC Symbol)

Synonyms

 HOX2, HOX2G

Description

 Homeobox B3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48548870 - 48604912

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120093 (version 83.38)

Entrez gene

 3213

UniProt

 P14651 (UniProt - Evidence at transcript level)

neXtProt

 NX_P14651

Antibodypedia

 HOXB3 antibodies

PROTEIN BROWSER
HOXB3-001
HOXB3-002
HOXB3-003
HOXB3-004
HOXB3-005
HOXB3-006
HOXB3-007
HOXB3-008
HOXB3-009
HOXB3-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXB3-001
ENSP00000417207
ENST00000470495
P14651 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009952 [anterior/posterior pattern specification]
GO:0021546 [rhombomere development]
GO:0021615 [glossopharyngeal nerve morphogenesis]
GO:0030878 [thyroid gland development]
GO:0043565 [sequence-specific DNA binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0050767 [regulation of neurogenesis]
GO:0051216 [cartilage development]
GO:0060216 [definitive hemopoiesis]
GO:0060324 [face development]
Show all
 431 aa
44.3 kDa 		No 0
HOXB3-002
ENSP00000420595
ENST00000498678
P14651 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 431 aa
44.3 kDa 		No 0
HOXB3-003
ENSP00000419676
ENST00000472863
P14651 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 358 aa
36.7 kDa 		No 0
HOXB3-004
ENSP00000418892
ENST00000476342
P14651 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 431 aa
44.3 kDa 		No 0
HOXB3-005
ENSP00000418729
ENST00000489475
P14651 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 358 aa
36.7 kDa 		No 0
HOXB3-006
ENSP00000418035
ENST00000460160
P14651 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 299 aa
31 kDa 		No 0
HOXB3-007
ENSP00000308252
ENST00000311626
P14651 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 431 aa
44.3 kDa 		No 0
HOXB3-008
ENSP00000449977
ENST00000490677
F8VXG0 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 297 aa
30.9 kDa 		No 0
HOXB3-009
ENSP00000446783
ENST00000465120
F8W1L2 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Show all
 119 aa
13.4 kDa 		No 0
HOXB3-012
ENSP00000417400
ENST00000471459
C9J2I3 [Direct mapping]
Homeobox protein Hox-B3
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 90 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.