Cell atlas - HOXB3 - The Human Protein Atlas

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HOXB3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HOXB3
Gene description	Homeobox B3
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enhanced (HEK 293, CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA064990
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293, CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064990	HEK 293	Nucleus
	HPA064990	HeLa	Nucleoplasm
	HPA064990	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	HOXB3 (HGNC Symbol)
Synonyms	HOX2, HOX2G
Description	Homeobox B3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	48548870 - 48604912
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120093 (version 83.38)
Entrez gene	3213
UniProt	P14651 (UniProt - Evidence at transcript level)
neXtProt	NX_P14651
Antibodypedia	HOXB3 antibodies

PROTEIN BROWSER

HOXB3-001	HOXB3-002	HOXB3-003	HOXB3-004	HOXB3-005	HOXB3-006	HOXB3-007	HOXB3-008	HOXB3-009	HOXB3-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXB3-001 ENSP00000417207 ENST00000470495	P14651 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001525 [angiogenesis] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0009952 [anterior/posterior pattern specification] GO:0021546 [rhombomere development] GO:0021615 [glossopharyngeal nerve morphogenesis] GO:0030878 [thyroid gland development] GO:0043565 [sequence-specific DNA binding] GO:0048704 [embryonic skeletal system morphogenesis] GO:0050767 [regulation of neurogenesis] GO:0051216 [cartilage development] GO:0060216 [definitive hemopoiesis] GO:0060324 [face development] Show all	431 aa 44.3 kDa	No	0
HOXB3-002 ENSP00000420595 ENST00000498678	P14651 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0001525 [angiogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	431 aa 44.3 kDa	No	0
HOXB3-003 ENSP00000419676 ENST00000472863	P14651 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0001525 [angiogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	358 aa 36.7 kDa	No	0
HOXB3-004 ENSP00000418892 ENST00000476342	P14651 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0001525 [angiogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	431 aa 44.3 kDa	No	0
HOXB3-005 ENSP00000418729 ENST00000489475	P14651 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0001525 [angiogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	358 aa 36.7 kDa	No	0
HOXB3-006 ENSP00000418035 ENST00000460160	P14651 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0001525 [angiogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	299 aa 31 kDa	No	0
HOXB3-007 ENSP00000308252 ENST00000311626	P14651 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0001525 [angiogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	431 aa 44.3 kDa	No	0
HOXB3-008 ENSP00000449977 ENST00000490677	F8VXG0 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	297 aa 30.9 kDa	No	0
HOXB3-009 ENSP00000446783 ENST00000465120	F8W1L2 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Show all		119 aa 13.4 kDa	No	0
HOXB3-012 ENSP00000417400 ENST00000471459	C9J2I3 [Direct mapping] Homeobox protein Hox-B3 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	90 aa 8.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.