Expression of EXOSC8 in cancer - Summary

CANCER ATLAS

Gene description

Exosome component 8

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039702	HPA043942	CAB034240

GENE INFORMATION
Gene name	EXOSC8 (HGNC Symbol)
Synonyms	bA421P11.3, CIP3, EAP2, OIP2, p9, RRP43, Rrp43p
Description	Exosome component 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	36998816 - 37009613
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000120699 (version 83.38)
Entrez gene	11340
UniProt	Q96B26 (UniProt - Evidence at protein level)
neXtProt	NX_Q96B26
Antibodypedia	EXOSC8 antibodies

PROTEIN BROWSER

EXOSC8-001	EXOSC8-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXOSC8-001 ENSP00000419203 ENST00000481013	H7C581 [Direct mapping] Exosome complex component RRP43 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.6 kDa	No	0
EXOSC8-003 ENSP00000374354 ENST00000389704	Q96B26 [Direct mapping] Exosome complex component RRP43 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000176 [nuclear exosome (RNase complex)] GO:0000177 [cytoplasmic exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008150 [biological_process] GO:0010467 [gene expression] GO:0017091 [AU-rich element binding] GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'] GO:0034473 [U1 snRNA 3'-end processing] GO:0034475 [U4 snRNA 3'-end processing] GO:0034476 [U5 snRNA 3'-end processing] GO:0043488 [regulation of mRNA stability] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0044822 [poly(A) RNA binding] GO:0071028 [nuclear mRNA surveillance] GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process] GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process] GO:0071042 [nuclear polyadenylation-dependent mRNA catabolic process] Show all	276 aa 30 kDa	No	0