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EXOSC8

GENERAL INFORMATION

Gene name

 EXOSC8

Gene description

 Exosome component 8

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 3 antibodies.
HPA039702 , HPA043942 , CAB034240
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EXOSC8 (HGNC Symbol)

Synonyms

 bA421P11.3, CIP3, EAP2, OIP2, p9, RRP43, Rrp43p

Description

 Exosome component 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]

Chromosome

 13

Cytoband

 q13.3

Chromosome location (bp)

 36998816 - 37009613

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120699 (version 83.38)

Entrez gene

 11340

UniProt

 Q96B26 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96B26

Antibodypedia

 EXOSC8 antibodies

PROTEIN BROWSER
EXOSC8-001
EXOSC8-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOSC8-001
ENSP00000419203
ENST00000481013
H7C581 [Direct mapping]
Exosome complex component RRP43
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 69 aa
7.6 kDa 		No 0
EXOSC8-003
ENSP00000374354
ENST00000389704
Q96B26 [Direct mapping]
Exosome complex component RRP43
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008150 [biological_process]
GO:0010467 [gene expression]
GO:0017091 [AU-rich element binding]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034473 [U1 snRNA 3'-end processing]
GO:0034475 [U4 snRNA 3'-end processing]
GO:0034476 [U5 snRNA 3'-end processing]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0071028 [nuclear mRNA surveillance]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071042 [nuclear polyadenylation-dependent mRNA catabolic process]
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 276 aa
30 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.