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NR2C1

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GENERAL INFORMATION

Gene name

 NR2C1

Gene description

 Nuclear receptor subfamily 2, group C, member 1

Protein class

 Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol & cell junctions.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Cell Junctions (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA035040 , HPA035041
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol & cell junctions.

Main location

 Nucleus (supported)

Additional location

 Cell Junctions (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035040 A-431 Nucleus
Cell Junctions
HPA035040 HEK 293 Nucleus
Cell Junctions
Aggresome
HPA035040 U-2 OS Nucleus
Plasma membrane
HPA035041 A-431 Nucleoplasm
Cytosol
HPA035041 HEK 293 Nucleoplasm
Cytosol
HPA035041 U-2 OS Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 NR2C1 (HGNC Symbol)

Synonyms

 TR2, TR2-11

Description

 Nuclear receptor subfamily 2, group C, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q22

Chromosome location (bp)

 95020229 - 95073703

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120798 (version 83.38)

Entrez gene

 7181

UniProt

 P13056 (UniProt - Evidence at protein level)

neXtProt

 NX_P13056

Antibodypedia

 NR2C1 antibodies

PROTEIN BROWSER
NR2C1-001
NR2C1-002
NR2C1-004
NR2C1-009
NR2C1-018
NR2C1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR2C1-001
ENSP00000333275
ENST00000333003
P13056 [Direct mapping]
Nuclear receptor subfamily 2 group C member 1
H9NIM2 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 2, group C, member 1, isoform CRA_c; Testicular nuclear receptor 2 variant 1
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Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016605 [PML body]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048386 [positive regulation of retinoic acid receptor signaling pathway]
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 603 aa
67.3 kDa 		No 0
NR2C1-002
ENSP00000376813
ENST00000393101
P13056 [Direct mapping]
Nuclear receptor subfamily 2 group C member 1
H9NIM3 [Target identity:100%; Query identity:100%]
Testicular nuclear receptor 2 variant 2
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Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016605 [PML body]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 467 aa
51.2 kDa 		No 0
NR2C1-004
ENSP00000328843
ENST00000330677
P13056 [Direct mapping]
Nuclear receptor subfamily 2 group C member 1
Show all
Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016605 [PML body]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 483 aa
53 kDa 		No 0
NR2C1-009
ENSP00000446906
ENST00000547469
F8W1Q1 [Direct mapping]
Nuclear receptor subfamily 2 group C member 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 16 aa
1.9 kDa 		No 0
NR2C1-018
ENSP00000450225
ENST00000551647
H0YIV1 [Direct mapping]
Nuclear receptor subfamily 2 group C member 1
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   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043401 [steroid hormone mediated signaling pathway]
Show all
 73 aa
8.1 kDa 		No 0
NR2C1-201
ENSP00000478728
ENST00000622476
A0A087WUK4 [Direct mapping]
Nuclear receptor subfamily 2 group C member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 434 aa
47.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.