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EPHX2

GENERAL INFORMATION

Gene name

 EPHX2

Gene description

 Epoxide hydrolase 2, cytoplasmic

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA023094 , HPA023660
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EPHX2

Synonyms

Description

 Epoxide hydrolase 2, cytoplasmic (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Chromosome

 8

Cytoband

Chromosome location (bp)

 27490779 - 27545564

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000120915 (version 83.38)

Entrez gene

 2053

UniProt

 P34913 (UniProt - Evidence at protein level)

neXtProt

 NX_P34913

Antibodypedia

 EPHX2 antibodies

PROTEIN BROWSER
EPHX2-001
EPHX2-002
EPHX2-003
EPHX2-005
EPHX2-008
EPHX2-011
EPHX2-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPHX2-001
ENSP00000430269
ENST00000521400
P34913 [Direct mapping]
Bifunctional epoxide hydrolase 2 Cytosolic epoxide hydrolase 2 Lipid-phosphate phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004301 [epoxide hydrolase activity]
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006954 [inflammatory response]
GO:0008152 [metabolic process]
GO:0008217 [regulation of blood pressure]
GO:0009636 [response to toxic substance]
GO:0010628 [positive regulation of gene expression]
GO:0015643 [toxic substance binding]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0017144 [drug metabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0033885 [10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity]
GO:0042577 [lipid phosphatase activity]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045909 [positive regulation of vasodilation]
GO:0046272 [stilbene catabolic process]
GO:0046839 [phospholipid dephosphorylation]
GO:0070062 [extracellular exosome]
GO:0072593 [reactive oxygen species metabolic process]
GO:0090181 [regulation of cholesterol metabolic process]
Show all
 555 aa
62.6 kDa 		No 0
EPHX2-002
ENSP00000369843
ENST00000380476
P34913 [Direct mapping]
Bifunctional epoxide hydrolase 2 Cytosolic epoxide hydrolase 2 Lipid-phosphate phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004301 [epoxide hydrolase activity]
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006954 [inflammatory response]
GO:0008152 [metabolic process]
GO:0008217 [regulation of blood pressure]
GO:0009636 [response to toxic substance]
GO:0010628 [positive regulation of gene expression]
GO:0015643 [toxic substance binding]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0017144 [drug metabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0033885 [10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity]
GO:0042577 [lipid phosphatase activity]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045909 [positive regulation of vasodilation]
GO:0046272 [stilbene catabolic process]
GO:0046839 [phospholipid dephosphorylation]
GO:0070062 [extracellular exosome]
GO:0072593 [reactive oxygen species metabolic process]
GO:0090181 [regulation of cholesterol metabolic process]
Show all
 502 aa
57.1 kDa 		No 0
EPHX2-003
ENSP00000428875
ENST00000517536
E5RFH6 [Direct mapping]
Bifunctional epoxide hydrolase 2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
Show all
 372 aa
42.1 kDa 		No 0
EPHX2-005
ENSP00000427956
ENST00000518379
E5RFU2 [Direct mapping]
Bifunctional epoxide hydrolase 2
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 523 aa
58.9 kDa 		No 0
EPHX2-008
ENSP00000430302
ENST00000521780
P34913 [Direct mapping]
Bifunctional epoxide hydrolase 2 Cytosolic epoxide hydrolase 2 Lipid-phosphate phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004301 [epoxide hydrolase activity]
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006954 [inflammatory response]
GO:0008152 [metabolic process]
GO:0008217 [regulation of blood pressure]
GO:0009636 [response to toxic substance]
GO:0010628 [positive regulation of gene expression]
GO:0015643 [toxic substance binding]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0017144 [drug metabolic process]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0033885 [10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity]
GO:0042577 [lipid phosphatase activity]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045909 [positive regulation of vasodilation]
GO:0046272 [stilbene catabolic process]
GO:0046839 [phospholipid dephosphorylation]
GO:0070062 [extracellular exosome]
GO:0072593 [reactive oxygen species metabolic process]
GO:0090181 [regulation of cholesterol metabolic process]
Show all
 489 aa
55.6 kDa 		No 0
EPHX2-011
ENSP00000430779
ENST00000518328
E5RI53 [Direct mapping]
Bifunctional epoxide hydrolase 2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 158 aa
17.6 kDa 		No 0
EPHX2-017
ENSP00000428191
ENST00000521684
H0YAW7 [Direct mapping]
Bifunctional epoxide hydrolase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 312 aa
34.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.