Expression of AKAP1 in cancer - Summary

CANCER ATLAS

Gene description

A kinase (PRKA) anchor protein 1

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008691	CAB019286

GENE INFORMATION
Gene name	AKAP1 (HGNC Symbol)
Synonyms	AKAP121, AKAP149, AKAP84, D-AKAP1, PPP1R43, PRKA1, S-AKAP84, SAKAP84, TDRD17
Description	A kinase (PRKA) anchor protein 1 (HGNC Symbol)
Entrez gene summary	The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q22
Chromosome location (bp)	57085092 - 57121349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121057 (version 83.38)
Entrez gene	8165
UniProt	Q92667 (UniProt - Evidence at protein level)
neXtProt	NX_Q92667
Antibodypedia	AKAP1 antibodies

PROTEIN BROWSER

AKAP1-001	AKAP1-003	AKAP1-005	AKAP1-006	AKAP1-008	AKAP1-009	AKAP1-010	AKAP1-011	AKAP1-012	AKAP1-013	AKAP1-014	AKAP1-015	AKAP1-016	AKAP1-017	AKAP1-018	AKAP1-201	AKAP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKAP1-001 ENSP00000337736 ENST00000337714	Q92667 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034237 [protein kinase A regulatory subunit binding] GO:0044822 [poly(A) RNA binding] Show all	903 aa 97.3 kDa	No	1
AKAP1-003 ENSP00000459968 ENST00000571629	Q92667 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034237 [protein kinase A regulatory subunit binding] GO:0044822 [poly(A) RNA binding] Show all	903 aa 97.3 kDa	No	1
AKAP1-005 ENSP00000459895 ENST00000572557	Q92667 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034237 [protein kinase A regulatory subunit binding] GO:0044822 [poly(A) RNA binding] Show all	903 aa 97.3 kDa	No	1
AKAP1-006 ENSP00000443139 ENST00000539273	Q92667 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034237 [protein kinase A regulatory subunit binding] GO:0044822 [poly(A) RNA binding] Show all	903 aa 97.3 kDa	No	1
AKAP1-008 ENSP00000459808 ENST00000575322	I3L2N7 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	186 aa 20.3 kDa	No	1
AKAP1-009 ENSP00000461418 ENST00000575186	A0A0G2JLF7 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		8 aa 1 kDa	No	0
AKAP1-010 ENSP00000458982 ENST00000570423		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		7 aa 0.9 kDa	No	0
AKAP1-011 ENSP00000458164 ENST00000572814	I3L0K6 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	137 aa 15.1 kDa	No	1
AKAP1-012 ENSP00000460557 ENST00000573085	I3L3L9 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	47 aa 5.4 kDa	No	1
AKAP1-013 ENSP00000460209 ENST00000574683	I3L364 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	95 aa 10.4 kDa	No	1
AKAP1-014 ENSP00000460514 ENST00000576591	I3L3K1 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	83 aa 9.2 kDa	No	1
AKAP1-015 ENSP00000458378 ENST00000576295	I3L0W0 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	204 aa 21.8 kDa	No	0
AKAP1-016 ENSP00000460762 ENST00000575032	I3L3V6 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		179 aa 19.8 kDa	No	0
AKAP1-017 ENSP00000458370 ENST00000572560	I3L0V5 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.1 kDa	No	0
AKAP1-018 ENSP00000459521 ENST00000572156	I3L2A2 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	183 aa 20 kDa	No	1
AKAP1-201 ENSP00000314075 ENST00000314126	Q92667 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034237 [protein kinase A regulatory subunit binding] GO:0044822 [poly(A) RNA binding] Show all	593 aa 62.9 kDa	No	1
AKAP1-202 ENSP00000478212 ENST00000621116	Q92667 [Direct mapping] A-kinase anchor protein 1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0007596 [blood coagulation] GO:0008017 [microtubule binding] GO:0010614 [negative regulation of cardiac muscle hypertrophy] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019904 [protein domain specific binding] GO:0030061 [mitochondrial crista] GO:0030346 [protein phosphatase 2B binding] GO:0031594 [neuromuscular junction] GO:0032947 [protein complex scaffold] GO:0034237 [protein kinase A regulatory subunit binding] GO:0035308 [negative regulation of protein dephosphorylation] GO:0044822 [poly(A) RNA binding] GO:0045211 [postsynaptic membrane] GO:0048487 [beta-tubulin binding] GO:0051534 [negative regulation of NFAT protein import into nucleus] GO:0071320 [cellular response to cAMP] GO:0071375 [cellular response to peptide hormone stimulus] Show all	903 aa 97.3 kDa	No	1