Tissue expression of SCPEP1 - Summary - The Human Protein Atlas

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SCPEP1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SCPEP1
Gene description	Serine carboxypeptidase 1
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression, most abundant in glandular cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA039102 , HPA057200
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SCPEP1 (HGNC Symbol)
Synonyms	RISC
Description	Serine carboxypeptidase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q22
Chromosome location (bp)	56978105 - 57006768
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121064 (version 83.38)
Entrez gene	59342
UniProt	Q9HB40 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HB40
Antibodypedia	SCPEP1 antibodies

PROTEIN BROWSER

SCPEP1-001	SCPEP1-005	SCPEP1-006	SCPEP1-012	SCPEP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCPEP1-001 ENSP00000262288 ENST00000262288	Q9HB40 [Direct mapping] Retinoid-inducible serine carboxypeptidase Show all	Enzymes Peptidases Serine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0042573 [retinoic acid metabolic process] GO:0045776 [negative regulation of blood pressure] GO:0045909 [positive regulation of vasodilation] GO:0070062 [extracellular exosome] Show all	452 aa 50.8 kDa	Yes	0
SCPEP1-005 ENSP00000461694 ENST00000575395	I3L506 [Direct mapping] Retinoid-inducible serine carboxypeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	95 aa 10.4 kDa	No	0
SCPEP1-006 ENSP00000461663 ENST00000572710	I3L4Z3 [Direct mapping] Retinoid-inducible serine carboxypeptidase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	176 aa 19.7 kDa	Yes	0
SCPEP1-012 ENSP00000461678 ENST00000573239	I3L4Z9 [Direct mapping] Retinoid-inducible serine carboxypeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	135 aa 15.4 kDa	No	0
SCPEP1-201 ENSP00000487541 ENST00000631024	I3L2N6 [Direct mapping] Retinoid-inducible serine carboxypeptidase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	147 aa 16.5 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.