Expression of TBX4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

T-box 4

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB032413

GENE INFORMATION
Gene name	TBX4
Synonyms
Description	T-box 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.2
Chromosome location (bp)	61452404 - 61485110
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121075 (version 83.38)
Entrez gene	9496
UniProt	P57082 (UniProt - Evidence at protein level)
neXtProt	NX_P57082
Antibodypedia	TBX4 antibodies

PROTEIN BROWSER

TBX4-001	TBX4-002	TBX4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBX4-001 ENSP00000377435 ENST00000393853	P57082 [Direct mapping] T-box transcription factor TBX4 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0035108 [limb morphogenesis] GO:0048705 [skeletal system morphogenesis] Show all	546 aa 60.3 kDa	No	0
TBX4-002 ENSP00000240335 ENST00000240335	P57082 [Direct mapping] T-box transcription factor TBX4 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0001525 [angiogenesis] GO:0002009 [morphogenesis of an epithelium] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0030324 [lung development] GO:0030326 [embryonic limb morphogenesis] GO:0035108 [limb morphogenesis] GO:0048705 [skeletal system morphogenesis] Show all	545 aa 60.2 kDa	No	0
TBX4-003 ENSP00000467588 ENST00000589003	K7EPY2 [Direct mapping] T-box transcription factor TBX4 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	135 aa 15.5 kDa	No	0