Tissue expression of TBX4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TBX4
Gene description	T-box 4
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (lung, placenta, prostate)
GTEx:	Group enriched (lung, urinary bladder, prostate)
FANTOM5:	Tissue enhanced (lung, smooth muscle, urinary bladder, prostate)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB032413
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, placenta, prostate)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, urinary bladder, prostate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, smooth muscle, urinary bladder, prostate)

GENE INFORMATION
Gene name	TBX4
Synonyms
Description	T-box 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.2
Chromosome location (bp)	61452404 - 61485110
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121075 (version 83.38)
Entrez gene	9496
UniProt	P57082 (UniProt - Evidence at protein level)
neXtProt	NX_P57082
Antibodypedia	TBX4 antibodies

PROTEIN BROWSER

TBX4-001	TBX4-002	TBX4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBX4-001 ENSP00000377435 ENST00000393853	P57082 [Direct mapping] T-box transcription factor TBX4 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0035108 [limb morphogenesis] GO:0048705 [skeletal system morphogenesis] Show all	546 aa 60.3 kDa	No	0
TBX4-002 ENSP00000240335 ENST00000240335	P57082 [Direct mapping] T-box transcription factor TBX4 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0001525 [angiogenesis] GO:0002009 [morphogenesis of an epithelium] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0030324 [lung development] GO:0030326 [embryonic limb morphogenesis] GO:0035108 [limb morphogenesis] GO:0048705 [skeletal system morphogenesis] Show all	545 aa 60.2 kDa	No	0
TBX4-003 ENSP00000467588 ENST00000589003	K7EPY2 [Direct mapping] T-box transcription factor TBX4 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	135 aa 15.5 kDa	No	0